{"doi":"10.1007/s00213-025-06751-9","title":"A humanized monoclonal antibody attenuates fentanyl self-administration and reverses and prevents fentanyl-induced ventilatory depression in rhesus monkeys","abstract":null,"journal":"Psychopharmacology","year":2025,"id":642774,"datarank":0.3563682290090098,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.010980465059902847,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.010980465059902847,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1414947,"name":"Courtney Marecki","orcid":null,"position":1,"is_corresponding":false},{"id":1071085,"name":"Caroline M. Kim","orcid":null,"position":2,"is_corresponding":false},{"id":280367,"name":"Takato Hiranita","orcid":null,"position":3,"is_corresponding":false},{"id":231704,"name":"Julia R. Taylor","orcid":"0000-0002-7549-0812","position":4,"is_corresponding":false},{"id":313538,"name":"David R. Maguire","orcid":"0000-0002-0958-5397","position":5,"is_corresponding":false},{"id":906927,"name":"Dustin Hicks","orcid":"0000-0002-6934-4050","position":6,"is_corresponding":false},{"id":1186412,"name":"Ann Gebo","orcid":"0009-0005-7860-5020","position":7,"is_corresponding":false},{"id":903010,"name":"Aaron Khaimraj","orcid":"0000-0002-2588-0900","position":8,"is_corresponding":false},{"id":756082,"name":"Carly Baehr","orcid":"0000-0002-3395-6776","position":9,"is_corresponding":false},{"id":298682,"name":"Marco Pravetoni","orcid":"0000-0003-1036-0184","position":10,"is_corresponding":false},{"id":313530,"name":"Charles P. France","orcid":"0000-0001-5157-6307","position":11,"is_corresponding":false},{"id":1672103,"name":"Lindsey K. Galbo-Thomma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A humanized monoclonal antibody attenuates fentanyl self-administration and reverses and prevents fentanyl-induced ventilatory depression in rhesus monkeys","abstract":"Medications for opioid use disorder (OUD) and overdose have been available for decades, yet nearly 70% of fatal drug overdoses in the United States are attributed to the opioid receptor agonist fentanyl and its analogs. There is a pressing need for more and better medications that reduce fentanyl use and prevent overdose. A humanized (h) monoclonal antibody (mAb) targeting fentanyl, hHY6-F9, was tested for attenuating intravenous fentanyl self-administration and reversing and preventing fentanyl-induced ventilatory depression in rhesus monkeys. A single administration of hHY6-F9 significantly decreased fentanyl, but not heroin or cocaine, self-administration. In some monkeys, fentanyl self-administration remained decreased for ~ 2 weeks. hHY6-F9 was as effective as 32 µg/kg naloxone in reversing fentanyl-induced ventilatory depression, with a single administration protecting against fentanyl-induced ventilatory depression for 2-3 weeks. Moreover, pharmacokinetic analyses indicate that hHY6-F9 continued to sequester fentanyl in the serum for 2 weeks. This study demonstrates that hHY6-F9 selectively attenuates the positive reinforcing and ventilatory depressant effects of fentanyl, indicating its possible utility for preventing relapse and overdose.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39907778","pmcid":"PMC12301107","openalex_id":"https://openalex.org/W4407182820","authors":[],"funders":[{"funder_name":"National Institute on Drug Abuse","grant_id":"U01DA51658","title":null},{"funder_name":"National Institute on Drug Abuse","grant_id":"UG3DA057850","title":null},{"funder_name":"National Institute on Drug Abuse","grant_id":"T32DA031115","title":null},{"funder_name":"Welch Foundation","grant_id":"AQ-0039","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"U01 DA051658","title":null},{"funder_name":"National Institutes of Health","grant_id":"1T32DA031115-01","title":"Training in Drug Abuse Research: Behavior and Neurobiology"},{"funder_name":"National Institutes of Health","grant_id":"1UG3DA057850-01","title":"Development of a monoclonal antibody to reverse overdose from fentanyl and its analogs: from manufacturing to clinical trials"},{"funder_name":"National Institutes of Health","grant_id":"7U01DA051658-03","title":"Antibody-based countermeasures against fentanyl and its analogues"}],"total_grants":8,"fwci":9.5033,"citation_percentile":0.98152143,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"green","license":"Springer Nature TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12301107","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12301107","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.1007/s00213-025-06751-9.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00213-025-06751-9/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00213-025-06751-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39907778","host_type":"repository"}],"fields_of_study":["Opioid Use Disorder Treatment","Treatment of Major Depression","Pain Mechanisms and Treatments","03 medical and health sciences","0305 other medical science","Animals","Macaca mulatta","Fentanyl","Self Administration","Antibodies, Monoclonal, Humanized","Analgesics, Opioid","Respiratory Insufficiency","Male","Narcotic Antagonists","Naloxone","Female","Opioid-Related Disorders"],"mesh_terms":["Analgesics, Opioid","Animals","Female","Fentanyl","Macaca mulatta","Male","Naloxone","Narcotic Antagonists","Opioid-Related Disorders","Respiratory Insufficiency","Self Administration","Antibodies, Monoclonal, Humanized"],"keywords":["Fentanyl","Self-administration","Depression (economics)","Monoclonal antibody","Medicine","Pharmacology","Anesthesia","Antibody","Immunology","Nonhuman Primate","Opioid Use Disorder","Male","Naloxone","Narcotic Antagonists","Self Administration","Antibodies, Monoclonal, Humanized","Opioid-Related Disorders","Macaca mulatta","Analgesics, Opioid","Animals","Female","Respiratory Insufficiency"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T03:40:53.004014Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}