{"doi":"10.1007/s00210-025-04297-3","title":"PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly activated in cancers. In CSCs, PI3K/AKT/mTOR pathway has been associated with attribution of various properties to cancer cells including stemness characteristics, proliferation, migration, epithelial to mesenchymal transition, and autophagy. Thus, targeting PI3K/AKT/mTOR pathway with novel inhibitors might help to control the growth and proliferation of the breast CSC population. Though many studies have focused on PI3K/AKT/mTOR pathway in breast cancer, limited literature is available on the role of PI3K/AKT/mTOR pathway in breast CSCs. Here, in our present review, we have highlighted the role of the PI3K/AKT/mTOR signaling pathway in breast CSCs and its applications in therapeutic targeting.</jats:p>","journal":"Naunyn-Schmiedeberg's Archives of Pharmacology","year":2025,"id":644740,"datarank":0.41388339313959843,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.04114739567139833,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.04114739567139833,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":10,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1678352,"name":"Shilpa Kuttikrishnan","orcid":null,"position":1,"is_corresponding":false},{"id":1678353,"name":"Zahwa Mariyam","orcid":null,"position":2,"is_corresponding":false},{"id":1678354,"name":"Ummu Habeeba","orcid":null,"position":3,"is_corresponding":false},{"id":1678355,"name":"Anu Jayanthi Panicker","orcid":null,"position":4,"is_corresponding":false},{"id":1678356,"name":"Tariq Masoodi","orcid":null,"position":5,"is_corresponding":false},{"id":680768,"name":"Kulsoom Junejo","orcid":null,"position":6,"is_corresponding":false},{"id":1184044,"name":"Shahab Uddin","orcid":"0000-0003-1886-6710","position":7,"is_corresponding":false},{"id":1289151,"name":"Kirti S. Prabhu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly activated in cancers. In CSCs, PI3K/AKT/mTOR pathway has been associated with attribution of various properties to cancer cells including stemness characteristics, proliferation, migration, epithelial to mesenchymal transition, and autophagy. Thus, targeting PI3K/AKT/mTOR pathway with novel inhibitors might help to control the growth and proliferation of the breast CSC population. Though many studies have focused on PI3K/AKT/mTOR pathway in breast cancer, limited literature is available on the role of PI3K/AKT/mTOR pathway in breast CSCs. Here, in our present review, we have highlighted the role of the PI3K/AKT/mTOR signaling pathway in breast CSCs and its applications in therapeutic targeting.</jats:p>","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40676293","pmcid":"PMC12678495","openalex_id":"https://openalex.org/W4412491342","authors":[],"funders":[{"funder_name":"Hamad Medical Corporation","grant_id":"IRGC-05-SI-18-307","title":null},{"funder_name":"Hamad Medical Corporation","grant_id":"","title":null}],"total_grants":2,"fwci":4.1085,"citation_percentile":0.94702099,"influential_citations":0,"citation_trend":[{"year":2026,"count":10}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00210-025-04297-3.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s00210-025-04297-3.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00210-025-04297-3/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00210-025-04297-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40676293","host_type":"repository"},{"url":"https://figshare.com/articles/journal_contribution/PI3_K_AKT_mTOR_pathway_and_its_role_in_breast_cancer_stem_cells/30455789","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12678495/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12678495","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12678495?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["PI3K/AKT/mTOR signaling in cancer","Polyamine Metabolism and Applications","Epigenetics and DNA Methylation","Humans","Neoplastic Stem Cells","TOR Serine-Threonine Kinases","Breast Neoplasms","Proto-Oncogene Proteins c-akt","Signal Transduction","Female","Animals","Phosphatidylinositol 3-Kinases","Antineoplastic Agents"],"mesh_terms":["Animals","Antineoplastic Agents","Breast Neoplasms","Female","Humans","Neoplastic Stem Cells","Signal Transduction","Phosphatidylinositol 3-Kinases","Proto-Oncogene Proteins c-akt","TOR Serine-Threonine Kinases"],"keywords":["PI3K/AKT/mTOR pathway","Protein kinase B","Cancer research","Autophagy","RPTOR","Breast cancer","Cancer stem cell","Biology","Cancer","Stem cell","Signal transduction","Cell biology","Apoptosis","Genetics","Cancer Stem Cells","Epithelial–mesenchymal Transition","Pi3/akt/mtor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:59:27.742585Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}