{"doi":"10.1007/s00198-014-3010-0","title":"Can vitamin D metabolite measurements facilitate a “treat-to-target” paradigm to guide vitamin D supplementation?","abstract":null,"journal":"Osteoporosis International","year":2015,"id":47153,"datarank":1.5939813354330097,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":1.094150658906729,"self_endowment_contribution":0.49983067652628066,"citer_contribution":1.094150658906729,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":24,"citers_with_citation_signal":23,"citers_with_endowment":23,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":217672,"name":"J. Lappe","orcid":null,"position":1,"is_corresponding":false},{"id":217673,"name":"R. J. Singh","orcid":null,"position":2,"is_corresponding":false},{"id":217674,"name":"S. Khosla","orcid":null,"position":3,"is_corresponding":false},{"id":217675,"name":"D. Krueger","orcid":null,"position":4,"is_corresponding":false},{"id":217676,"name":"M. K. Drezner","orcid":null,"position":5,"is_corresponding":false},{"id":217677,"name":"R. D. Blank","orcid":null,"position":6,"is_corresponding":false},{"id":217671,"name":"N. Binkley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Can vitamin D metabolite measurements facilitate a “treat-to-target” paradigm to guide vitamin D supplementation?","abstract":"<h4>Unlabelled</h4>Substantial variability exists in the serum 25(OH)D increase observed in response to vitamin D supplementation. Measurement of circulating cholecalciferol and 24,25(OH)₂D, as indicators of vitamin D absorption and degradation, respectively, account for approximately half of the variation in serum 25(OH)D observed following supplementation.<h4>Introduction</h4>Vitamin D supplementation produces a variable response in serum 25(OH)D. This variability likely reflects, in part, differences in vitamin D absorption and/or degradation. Despite this variation in response, virtually all expert recommendations endorse a fixed vitamin D supplementation dose, an approach also used in most prospective studies. Such utilization of a single vitamin D dose does not assure attaining any pre-specified target 25(OH)D level, thereby compromising clinical care and prospective supplementation trials. This study begins addressing this weakness by exploring the feasibility of vitamin D metabolite measurements to predict serum 25(OH)D level attained following supplementation.<h4>Methods</h4>Ninety-one community-dwelling postmenopausal women with baseline 25(OH)D of 10-30 ng/mL received oral vitamin D₃, 2300 or 2500 IU, daily for 4-6 months. Serum 25(OH)D, cholecalciferol (D₃), and 24,25(OH)₂D were measured before and at the end of supplementation to determine if metabolite concentrations allow prediction of the 25(OH)D level attained.<h4>Results</h4>From baseline and follow-up data, we derived a multiple linear regression model predicting posttreatment 25(OH)D as follows: final 25(OH)D = 8.3 + (1.05*initial 25(OH)D) - (7.7*initial 24,25(OH)₂D) + (0.53*final D₃) + (4.2*final 24,25(OH)₂D). This model has an adjusted R(2) = 0.55, thus accounting for approximately half of the observed variance in the final 25(OH)D level.<h4>Conclusions</h4>The contributions of circulating cholecalciferol and 24,25(OH)₂D to this predictive model can be considered as indicators of intestinal absorption and clearance, respectively. This paradigm requires further study; it may allow efficient \"treat-to-25(OH)D-target\" strategies useful in optimizing prospective studies and clinical practice.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25572049","pmcid":"PMC4412341","openalex_id":"https://openalex.org/W1998332739","authors":[],"funders":[{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR027032","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR054753","title":null},{"funder_name":"RRD VA","grant_id":"I21 RX001440","title":null}],"total_grants":3,"fwci":2.6085,"citation_percentile":0.88664961,"influential_citations":0,"citation_trend":[{"year":2016,"count":5},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":6},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":3}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412341","host_type":"GREEN"},{"url":"http://link.springer.com/content/pdf/10.1007/s00198-014-3010-0.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00198-014-3010-0/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00198-014-3010-0","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00198-014-3010-0","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25572049","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4412341","host_type":"repository"}],"fields_of_study":["Vitamin D Research Studies","Bone health and osteoporosis research","Vitamin K Research Studies","Medicine","24,25-Dihydroxyvitamin D 3","Aged","Bone Density Conservation Agents","Cholecalciferol","Dietary Supplements","Drug Monitoring","Female","Follow-Up Studies","Humans","Middle Aged","Osteoporosis, Postmenopausal","Vitamin D"],"mesh_terms":["Aged","Cholecalciferol","Female","Follow-Up Studies","Humans","Middle Aged","Vitamin D","24,25-Dihydroxyvitamin D 3","Osteoporosis, Postmenopausal","Drug Monitoring","Dietary Supplements","Bone Density Conservation Agents"],"keywords":["Vitamin D and neurology","Cholecalciferol","Medicine","Metabolite","vitamin D deficiency","Ergocalciferol","Internal medicine","Vitamin","Endocrinology","Prospective cohort study"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-17T10:11:30.494487Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}