{"doi":"10.1007/s00125-019-4880-7","title":"Genome-wide association study of type 2 diabetes in Africa","abstract":null,"journal":"Diabetologia","year":2019,"id":607737,"datarank":0.7023196840686331,"base_score":4.68213122712422,"endowment":4.68213122712422,"self_citation_contribution":0.7023196840686331,"citation_network_contribution":0.0,"self_endowment_contribution":0.7023196840686331,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":107,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":169653,"name":"Meng Sun","orcid":null,"position":1,"is_corresponding":false},{"id":231134,"name":"Adebowale Adeyemo","orcid":"0000-0002-3105-3231","position":2,"is_corresponding":false},{"id":814019,"name":"Fraser Pirie","orcid":null,"position":3,"is_corresponding":false},{"id":395852,"name":"Tommy Carstensen","orcid":"0000-0002-3672-9931","position":4,"is_corresponding":false},{"id":404890,"name":"Cristina Pomilla","orcid":"0000-0002-2581-8365","position":5,"is_corresponding":false},{"id":255884,"name":"Ayo P. Doumatey","orcid":"0000-0001-9494-7710","position":6,"is_corresponding":false},{"id":130260,"name":"Guanjie Chen","orcid":null,"position":7,"is_corresponding":false},{"id":1560616,"name":"Elizabeth H. Young","orcid":null,"position":8,"is_corresponding":false},{"id":90151,"name":"Manjinder Sandhu","orcid":null,"position":9,"is_corresponding":false},{"id":16092,"name":"Andrew P. Morris","orcid":"0000-0002-6805-6014","position":10,"is_corresponding":false},{"id":21995,"name":"Inês Barroso","orcid":"0000-0001-5800-4520","position":11,"is_corresponding":false},{"id":1089,"name":"Mark I. McCarthy","orcid":"0000-0002-4393-0510","position":12,"is_corresponding":false},{"id":614739,"name":"Anubha Mahajan","orcid":"0000-0001-5314-2641","position":13,"is_corresponding":false},{"id":51457,"name":"Eleanor Wheeler","orcid":"0000-0002-8616-6444","position":14,"is_corresponding":false},{"id":35213,"name":"Charles N. Rotimi","orcid":"0000-0001-5759-053X","position":15,"is_corresponding":false},{"id":7884,"name":"Ayesha A. Motala","orcid":"0000-0003-0517-1784","position":16,"is_corresponding":false},{"id":153860,"name":"Ji Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genome-wide association study of type 2 diabetes in Africa","abstract":"Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic analysis in African populations. We conducted two type 2 diabetes genome-wide association studies in 4347 Africans from South Africa, Nigeria, Ghana and Kenya and meta-analysed both studies together. Likely causal variants were identified using fine-mapping approaches. The most significantly associated variants mapped to the widely replicated type 2 diabetes risk locus near TCF7L2 ( p = 5.3 × 10 −13 ). Fine-mapping of the TCF7L2 locus suggested one type 2 diabetes association signal shared between Europeans and Africans (indexed by rs7903146) and a distinct African-specific signal (indexed by rs17746147). We also detected one novel signal, rs73284431, near AGMO ( p = 5.2 × 10 −9 , minor allele frequency [MAF] = 0.095; monomorphic in most non-African populations), distinct from previously reported signals in the region. In analyses focused on 100 published type 2 diabetes risk loci, we identified 21 with shared causal variants in African and non-African populations. These results demonstrate the value of performing GWAS in Africans, provide a resource to larger consortia for further discovery and fine-mapping and indicate that additional large-scale efforts in Africa are warranted to gain further insight in to the genetic architecture of type 2 diabetes.","is_dataset_classified":null,"base_score":4.68213122712422,"endowment":4.68213122712422,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31049640","pmcid":"PMC6560001","openalex_id":"https://openalex.org/W2943730265","authors":[],"funders":[{"funder_name":"Wellcome","grant_id":"WT206194","title":null},{"funder_name":"CRGGH","grant_id":"1ZIAHG200362","title":null},{"funder_name":"MRC","grant_id":"G0601261","title":"Translating genome-wide association data from the WTCCC study into biological and clinical insights in type 2 diabetes"},{"funder_name":"NIH","grant_id":"U01DK105535","title":null},{"funder_name":"Wellcome Trust","grant_id":"106130","title":null},{"funder_name":"Wellcome Trust","grant_id":"106130/Z/14/Z","title":null},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"NF-SI-0617-10090","title":null},{"funder_name":"Wellcome Trust","grant_id":"098381","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"ZIA HG200362","title":null},{"funder_name":"Wellcome Trust","grant_id":"090367","title":null},{"funder_name":"Wellcome Trust","grant_id":"203141","title":"Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics"},{"funder_name":"NIDDK NIH HHS","grant_id":"U01 DK085545","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK098032","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/K013491/1","title":null},{"funder_name":"Wellcome Trust","grant_id":"090532","title":"Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics."},{"funder_name":"National Institutes of Health","grant_id":"5U01DK085545-02","title":"Identifying variants causal for Type 2 Diabetes in Major human populations"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK098032-02","title":"The Impact of Human Gene Knockouts in Type 2 Diabetes and Related Traits"},{"funder_name":"National Institutes of Health","grant_id":"7U01DK105535-06","title":"Integrating genome-scale data to reveal causal mechanisms in type 2 diabetes"},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"454382","title":"A prospective single arm trial of involved-field radiotherapy for stage I-II low grade nongastric marginal zone lymphoma"},{"funder_name":"National Institutes of Health","grant_id":"1ZIAHG200362-06","title":"Genetic epidemiology of complex diseases"},{"funder_name":"Wellcome Trust","grant_id":"206194","title":"Wellcome Trust Sanger Institute - 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