{"doi":"10.1007/s00117-004-1158-x","title":"Positronenemissionstomographie in den Neurowissenschaften","abstract":null,"journal":"Der Radiologe","year":2005,"id":621400,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1604587,"name":"B. Schaller","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Positronenemissionstomographie in den Neurowissenschaften","abstract":"The role of molecular neuroimaging techniques is increasing in the understanding of pathophysiological mechanism of diseases. To date, positron emission tomography is the most powerful tool for the non-invasive study of biochemical and molecular processes in humans and animals in vivo. With the development in radiochemistry and tracer technology, a variety of endogenously expressed and exogenously introduced genes can be analyzed by PET. This opens up the exciting and rapidly field of molecular imaging, aiming at the non-invasive localisation of a biological process of interest in normal and diseased cells in animal models and humans in vivo. Besides its usefulness for basic research positron emission tomography has been proven to be superior to conventional diagnostic methods in several clinical indications. This is illustrated by detection of biological or anatomic changes that cannot be demonstrated by computed tomography or magnetic resonance imaging, as well as even before symptoms are expressed. The present review summarizes the clinical use of positron emission tomography in neuroscience that has helped elucidate the pathophysiology of a number of diseases and has suggested strategies in the treatment of these patients. Special reference is given to the neurovascular, neurodegenerative and neurooncological disease.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15662519","pmcid":null,"openalex_id":"https://openalex.org/W1461663821","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.06511309,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00117-004-1158-x.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00117-004-1158-x/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00117-004-1158-x","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00117-004-1158-x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15662519","host_type":"repository"},{"url":"https://europepmc.org/article/MED/15662519","host_type":"journal"}],"fields_of_study":["Medical Imaging Techniques and Applications","Radiopharmaceutical Chemistry and Applications","Mitochondrial Function and Pathology","Animals","Brain","Clinical Trials as Topic","Humans","Molecular Biology","Nervous System Diseases","Neurosciences","Positron-Emission Tomography","Research Design"],"mesh_terms":["Animals","Brain","Clinical Trials as Topic","Humans","Molecular Biology","Nervous System Diseases","Neurosciences","Research Design","Positron-Emission Tomography"],"keywords":["Positron emission tomography","Molecular imaging","Medicine","Neuroimaging","Preclinical imaging","Neuroscience","Magnetic resonance imaging","Neurotransmitter systems","Neurovascular bundle","Brain positron emission tomography","In vivo","Medical physics","Pathology","Radiology","Psychology","Biology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T14:25:33.024860Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}