{"doi":"10.1007/s00066-008-1831-5","title":"A New Scoring System to Predicting the Survival of Patients Treated with Whole-Brain Radiotherapy for Brain Metastases","abstract":null,"journal":"Strahlentherapie und Onkologie","year":2008,"id":647303,"datarank":0.7091081728068512,"base_score":4.727387818712341,"endowment":4.727387818712341,"self_citation_contribution":0.7091081728068512,"citation_network_contribution":0.0,"self_endowment_contribution":0.7091081728068512,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":112,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1686364,"name":"Juergen Dunst","orcid":null,"position":1,"is_corresponding":false},{"id":630774,"name":"Steven E. Schild","orcid":"0000-0002-2850-4126","position":2,"is_corresponding":false},{"id":1192687,"name":"Dirk Rades","orcid":"0000-0002-3221-7541","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A New Scoring System to Predicting the Survival of Patients Treated with Whole-Brain Radiotherapy for Brain Metastases","abstract":"<h4>Purpose</h4>To create a scoring system to estimate survival of patients who received whole-brain radiotherapy (WBRT) for brain metastases.<h4>Material and methods</h4>Based on a multivariate analysis of 1,085 retrospectively analyzed patients, a scoring system was developed. This score was based on the four significant prognostic factors found in the multivariate analysis including: age, performance status, extracranial metastases at the time of WBRT, and interval between tumor diagnosis and WBRT. The score for each prognostic factor was determined by dividing the 6-month survival rate (in %) by 10. The total score represented the sum of the partial scores for each prognostic factor. Total scores ranged from 9 to 18 points, and patients were divided into four groups. For each group, survival was compared for short-course (5 x 4 Gy) versus longer-course WBRT (10 x 3 Gy/20 x 2 Gy).<h4>Results</h4>Actuarial 6-month survival rates were 6% for patients with scores of 9-10 points, 15% for those with scores of 11-13 points, 43% for those with scores of 14-16 points, and 76% for those with scores of 17-18 points (p < 0.001). Longer-course WBRT was not associated with better survival than short-course WBRT in any of the four groups.<h4>Conclusion</h4>Patients with brain metastases receiving WBRT can be grouped with this score to estimate survival. Short-course and longer-course WBRT resulted in similar survival in all groups studied. However, in the more favorable patients with scores of 17-18, longer-course WBRT with lower doses per fraction should be considered, as these schedules have been associated with less neurocognitive toxicity.","is_dataset_classified":null,"base_score":4.727387818712341,"endowment":4.727387818712341,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18427755","pmcid":null,"openalex_id":"https://openalex.org/W51480240","authors":[],"funders":[],"total_grants":0,"fwci":7.5923,"citation_percentile":0.97508237,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":11},{"year":2014,"count":9},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":8},{"year":2020,"count":8},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00066-008-1831-5.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00066-008-1831-5/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00066-008-1831-5","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00066-008-1831-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18427755","host_type":"repository"}],"fields_of_study":["Brain Metastases and Treatment","Glioma Diagnosis and Treatment","Lung Cancer Research Studies","Adult","Age Factors","Aged","Aged, 80 and over","Brain Neoplasms","Breast Neoplasms","Cranial Irradiation","Female","Humans","Kaplan-Meier Estimate","Karnofsky Performance Status","Lung Neoplasms","Male","Middle Aged","Multivariate Analysis","Prognosis","Radiotherapy Dosage","Retrospective Studies","Tumor Burden"],"mesh_terms":["Adult","Age Factors","Aged","Aged, 80 and over","Brain Neoplasms","Breast Neoplasms","Female","Humans","Lung Neoplasms","Male","Middle Aged","Prognosis","Radiotherapy Dosage","Retrospective Studies","Multivariate Analysis","Cranial Irradiation","Karnofsky Performance Status","Tumor Burden","Kaplan-Meier Estimate"],"keywords":["Medicine","Multivariate analysis","Whole brain radiotherapy","Radiation therapy","Overall survival","Recursive partitioning","Survival analysis","Internal medicine","Survival rate","Confidence interval","Surgery","Brain metastasis","Oncology","Metastasis","Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T17:53:26.633827Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}