{"doi":"10.1007/s00063-024-01243-8","title":"Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Objective</jats:title>\n                    <jats:p>To evaluate whether early mobilisation can reduce the incidence of delirium in critically ill patients and to assess the methodological quality of published studies.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Three electronic databases, PubMed, Embase and the Cochrane Library, were searched for relevant studies published up to 2 March 2024. Articles were screened independently by two reviewers, based on inclusion and exclusion criteria, and a meta-analysis was performed using RevMan 5.3 software with a random-effects model.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      A total of 18 studies (intervention group: 1794 participants, control group: 2129 participants) were included in the systematic review, with 18 studies included in the meta-analysis. Early mobilisation was found to reduce the risk of delirium in critically ill populations, with a pooled odds ratio of 0.65 (95% confidence interval [CI] 0.49–0.86;\n                      <jats:italic>P</jats:italic>\n                       = 0.003; I\n                      <jats:sup>2</jats:sup>\n                       = 59%). Additionally, two studies found that early mobilisation did not change the duration of delirium in critically ill populations, with a pooled mean difference of −1.53 (95% CI −3.48 to 0.41;\n                      <jats:italic>P</jats:italic>\n                       = 0.12; I\n                      <jats:sup>2</jats:sup>\n                       = 37%). Subgroup analysis revealed that early mobilisation maintained its preventive effect on delirium in the before/after intervention studies, studies published before 2018 and studies with a moderate methodological rating.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>As a nonpharmacological intervention, early mobilisation may help reduce the risk of delirium and shorten its duration in critically ill patients compared with standard treatment and may potentially become a novel strategy for delirium prevention in future intensive care unit settings.</jats:p>\n                  </jats:sec>","journal":"Medizinische Klinik - Intensivmedizin und Notfallmedizin","year":2025,"id":642013,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":761902,"name":"Fei Xie","orcid":"0000-0001-5285-4639","position":1,"is_corresponding":false},{"id":1669572,"name":"Yangyang Zeng","orcid":null,"position":2,"is_corresponding":false},{"id":396811,"name":"Xi Xia","orcid":"0000-0001-8297-6266","position":3,"is_corresponding":false},{"id":816285,"name":"Rui Wang","orcid":"0000-0001-8007-2503","position":4,"is_corresponding":false},{"id":1669574,"name":"Yongjie Cai","orcid":null,"position":5,"is_corresponding":false},{"id":744775,"name":"Yu Lei","orcid":"0000-0002-1610-9479","position":6,"is_corresponding":false},{"id":1669575,"name":"Fengjiao Xu","orcid":null,"position":7,"is_corresponding":false},{"id":1299612,"name":"Xi Li","orcid":"0009-0008-4480-8251","position":8,"is_corresponding":false},{"id":106141,"name":"Bing Chen","orcid":"0000-0002-8625-1657","position":9,"is_corresponding":false},{"id":1403010,"name":"Li Zhou","orcid":"0000-0003-3998-8725","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Objective</jats:title>\n                    <jats:p>To evaluate whether early mobilisation can reduce the incidence of delirium in critically ill patients and to assess the methodological quality of published studies.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Three electronic databases, PubMed, Embase and the Cochrane Library, were searched for relevant studies published up to 2 March 2024. Articles were screened independently by two reviewers, based on inclusion and exclusion criteria, and a meta-analysis was performed using RevMan 5.3 software with a random-effects model.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      A total of 18 studies (intervention group: 1794 participants, control group: 2129 participants) were included in the systematic review, with 18 studies included in the meta-analysis. Early mobilisation was found to reduce the risk of delirium in critically ill populations, with a pooled odds ratio of 0.65 (95% confidence interval [CI] 0.49–0.86;\n                      <jats:italic>P</jats:italic>\n                       = 0.003; I\n                      <jats:sup>2</jats:sup>\n                       = 59%). Additionally, two studies found that early mobilisation did not change the duration of delirium in critically ill populations, with a pooled mean difference of −1.53 (95% CI −3.48 to 0.41;\n                      <jats:italic>P</jats:italic>\n                       = 0.12; I\n                      <jats:sup>2</jats:sup>\n                       = 37%). Subgroup analysis revealed that early mobilisation maintained its preventive effect on delirium in the before/after intervention studies, studies published before 2018 and studies with a moderate methodological rating.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>As a nonpharmacological intervention, early mobilisation may help reduce the risk of delirium and shorten its duration in critically ill patients compared with standard treatment and may potentially become a novel strategy for delirium prevention in future intensive care unit settings.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40085206","pmcid":"PMC12708774","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"https://creativecommons.org/licenses/by/4.0/deed.de","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00063-024-01243-8.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00063-024-01243-8/fulltext.html","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC12708774","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12708774?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Humans","Delirium","Critical Illness","Early Ambulation","Incidence"],"keywords":["Rehabilitation","intervention","Delirium","Early Mobilisation","Non-drug Intervention"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T21:13:45.983430Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}