{"doi":"10.1007/s00018-024-05483-x","title":"Regulation of yeast polarized exocytosis by phosphoinositide lipids","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Phosphoinositides help steer membrane trafficking routes within eukaryotic cells. In polarized exocytosis, which targets vesicular cargo to sites of polarized growth at the plasma membrane (PM), the two phosphoinositides phosphatidylinositol 4-phosphate (PI4P) and its derivative phosphatidylinositol 4,5-bisphosphate (PI(4,5)P\n                    <jats:sub>2</jats:sub>\n                    ) pave the pathway for vesicle transport from the Golgi to the PM. PI4P is a critical regulator of mechanisms that shape late Golgi membranes for vesicle biogenesis and release. Although enriched in vesicle membranes, PI4P is inexplicably removed from post-Golgi vesicles during their transit to the PM, which drives subsequent steps in exocytosis. At the PM, PI(4,5)P\n                    <jats:sub>2</jats:sub>\n                    recruits effectors that establish polarized membrane sites for targeting the vesicular delivery of secretory cargo. The budding yeast\n                    <jats:italic>Saccharomyces cerevisiae</jats:italic>\n                    provides an elegant model to unravel the complexities of phosphoinositide regulation during polarized exocytosis. Here, we review how PI4P and PI(4,5)P\n                    <jats:sub>2</jats:sub>\n                    promote yeast vesicle biogenesis, exocyst complex assembly and vesicle docking at polarized cortical sites, and suggest how these steps might impact related mechanisms of human disease.\n                  </jats:p>","journal":"Cellular and Molecular Life Sciences","year":2024,"id":38996,"datarank":0.21386551199186254,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.00592135782387893,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.00592135782387893,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":192496,"name":"Aleksa Nenadic","orcid":null,"position":1,"is_corresponding":false},{"id":192497,"name":"Christopher T. Beh","orcid":"0000-0003-0201-6316","position":2,"is_corresponding":false},{"id":192495,"name":"Matthew W. Volpiana","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39560727","pmcid":"PMC11576722","openalex_id":"https://openalex.org/W4404519101","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"Discovery grant","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":2,"fwci":0.8771,"citation_percentile":0.72666945,"influential_citations":0,"citation_trend":[{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00018-024-05483-x.pdf","host_type":"journal"},{"url":"https://doi.org/10.1007/s00018-024-05483-x","host_type":"HYBRID"},{"url":"https://link.springer.com/content/pdf/10.1007/s00018-024-05483-x.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00018-024-05483-x/fulltext.html","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39560727","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11576722","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11576722/pdf/18_2024_Article_5483.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11576722","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11576722?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.21203/rs.3.rs-4932034/v1","host_type":""},{"url":"http://dx.doi.org/10.1007/s00018-024-05483-x","host_type":""}],"fields_of_study":["Cellular transport and secretion","Fungal and yeast genetics research","Lipid Membrane Structure and Behavior","Medicine","Biology","Exocytosis","Saccharomyces cerevisiae","Phosphatidylinositols","Cell Membrane","Golgi Apparatus","Phosphatidylinositol 4,5-Diphosphate","Phosphatidylinositol Phosphates","Saccharomyces cerevisiae Proteins","Humans"],"mesh_terms":["Cell Membrane","Exocytosis","Golgi Apparatus","Humans","Phosphatidylinositols","Saccharomyces cerevisiae","Phosphatidylinositol Phosphates","Phosphatidylinositol 4,5-Diphosphate","Saccharomyces cerevisiae Proteins"],"keywords":["Exocytosis","Cell biology","Vesicle","Vesicular transport protein","Golgi apparatus","Secretory Vesicle","Exocyst","Biology","Secretory pathway","Biogenesis","Vesicular Transport Proteins","Phosphatidylinositol","Vacuole","Secretion","Biochemistry","Membrane","Signal transduction","Endoplasmic reticulum","Cytoplasm","Rho GTPases","SEC2","Exocyst Complex","Pi(4,5)p2","Mss4","Polarized Exocytosis","Pi4p","Sac1","Rab Gtpases","Phosphoinositide Phosphatases","Phosphoinositide Kinases","Post-golgi Vesicle Transport","Pik1","Stt4","Phosphatidylinositol 4,5-Diphosphate","Saccharomyces cerevisiae Proteins","Phosphatidylinositol Phosphates","Cell Membrane","Humans","Review","Saccharomyces cerevisiae","Phosphatidylinositols"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T08:36:39.341332Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}