{"doi":"10.1007/s00018-020-03489-9","title":"Biological roles of LSD1 beyond its demethylase activity","abstract":null,"journal":"Cellular and Molecular Life Sciences","year":2020,"id":623669,"datarank":3.6360544841836626,"base_score":4.867534450455582,"endowment":4.867534450455582,"self_citation_contribution":0.7301301675683375,"citation_network_contribution":2.9059243166153252,"self_endowment_contribution":0.7301301675683375,"citer_contribution":2.9059243166153252,"corpus_percentile":null,"corpus_rank":null,"citation_count":129,"citer_count":105,"citers_with_citation_signal":91,"citers_with_endowment":91,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":818411,"name":"Yuxin Lin","orcid":"0000-0003-1758-6215","position":1,"is_corresponding":false},{"id":1611873,"name":"Zhun Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1611874,"name":"Xiaoxin Wu","orcid":null,"position":3,"is_corresponding":false},{"id":1611875,"name":"Zhenyue Ye","orcid":null,"position":4,"is_corresponding":false},{"id":1611877,"name":"Yuezhen Wang","orcid":null,"position":5,"is_corresponding":false},{"id":1598932,"name":"Huiyin Lan","orcid":"0000-0002-7925-0066","position":6,"is_corresponding":false},{"id":1611872,"name":"Feiying Gu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biological roles of LSD1 beyond its demethylase activity","abstract":"It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A) roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for regulating gene expression. Though the discovery of non-histone substrates methylated by LSD1 has largely expanded the functions of LSD1 as a typical demethylase, recent groundbreaking studies unveiled its non-catalytic functions as a second life for this demethylase. We and others found that LSD1 is implicated in the interaction with a line of proteins to exhibit additional non-canonical functions in a demethylase-independent manner. Here, we present an integrated overview of these recent literatures charging LSD1 with unforeseen functions to re-evaluate and summarize its non-catalytic biological roles beyond the current understanding of its demethylase activity. Given LSD1 is reported to be ubiquitously overexpressed in a variety of tumors, it has been generally considered as an innovative target for cancer therapy. We anticipate that these non-canonical functions of LSD1 will arouse the consideration that extending the LSD1-based drug discovery to targeting LSD1 protein interactions non-catalytically, not only its demethylase activity, may be a novel strategy for cancer prevention.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32193608","pmcid":"PMC11105033","openalex_id":null,"authors":[],"funders":[{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"20160171","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00018-020-03489-9.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00018-020-03489-9/fulltext.html","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Neoplasms","Proteasome Endopeptidase Complex","Histones","Autophagy","Ubiquitination","Histone Demethylases","Sequestosome-1 Protein","Demethylation","F-Box-WD Repeat-Containing Protein 7"],"keywords":["Ubiquitylation","Lsd1","Fbxw7","Demethylase","Non-catalytic"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T00:50:31.381506Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}