{"doi":"10.1007/pl00008082","title":"Endothelin-B receptor-mediated Ca2+ signaling in human melanocytes","abstract":null,"journal":"Pflügers Archiv","year":1998,"id":635158,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1647753,"name":"Won-Hyoung Kang","orcid":null,"position":1,"is_corresponding":false},{"id":1647754,"name":"C.-O. Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1609773,"name":"Hee-Young Kang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Endothelin-B receptor-mediated Ca2+ signaling in human melanocytes","abstract":"The mechanism of an endothelin-1- (ET-1-) induced intracellular Ca2+ ([Ca2+]i) increase and the receptor subtype(s) responsible for this effect in single human melanocytes were studied using fura-2/AM. ET-1 induced a transient increase in [Ca2+]i in a concentration-dependent manner. The transient [Ca2+]i increase was followed by a sustained plateau level of [Ca2+]i which was higher than the initial [Ca2+]i level. IRL-1620, a specific ET-B receptor agonist, increased [Ca2+]i in a dose-dependent manner. BQ-788, a specific ET-B receptor antagonist, abolished the ET-1-induced [Ca2+]i increase, but BQ-123, a specific ET-A receptor antagonist, failed to prevent it. U73122, an inhibitor of phospholipase C (PLC), inhibited the ET-1-induced [Ca2+]i rise in a dose-dependent manner. Prior depletion of intracellular Ca2+ stores with thapsigargin, an inhibitor of Ca2+-ATPase of the endoplasmic reticulum, abolished the ET-1-induced Ca2+ transient, whereas removal of extracellular Ca2+ with EGTA eliminated the sustained rise. These results suggest that in cultured human melanocytes the binding of ET-1 to ET-B receptors and the subsequent activation of PLC mediate ET-1-induced [Ca2+]i increase. The transient [Ca2+]i increase is attributed to mobilization of Ca2+ from inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ stores, and the sustained [Ca2+]i level may be related to the influx of extracellular Ca2+.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9426289","pmcid":null,"openalex_id":"https://openalex.org/W2314217253","authors":[],"funders":[],"total_grants":0,"fwci":0.449,"citation_percentile":0.63622333,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2024,"count":2}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/PL00008082.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/PL00008082/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/PL00008082","host_type":"publisher"},{"url":"https://doi.org/10.1007/pl00008082","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9426289","host_type":"repository"}],"fields_of_study":["melanin and skin pigmentation","Nitric Oxide and Endothelin Effects","Biochemical Analysis and Sensing Techniques","Calcium","Calcium-Transporting ATPases","Cells, Cultured","Egtazic Acid","Endothelin Receptor Antagonists","Endothelin-1","Endothelins","Enzyme Activation","Estrenes","Humans","Inositol 1,4,5-Trisphosphate","Male","Melanocytes","Peptide Fragments","Peptides, Cyclic","Pyrrolidinones","Receptor, Endothelin B","Receptors, Endothelin","Signal Transduction","Thapsigargin","Type C Phospholipases"],"mesh_terms":["Calcium-Transporting ATPases","Calcium","Cells, Cultured","Egtazic Acid","Enzyme Activation","Estrenes","Humans","Male","Melanocytes","Peptide Fragments","Peptides, Cyclic","Type C Phospholipases","Pyrrolidinones","Signal Transduction","Inositol 1,4,5-Trisphosphate","Endothelins","Receptors, Endothelin","Thapsigargin","Endothelin-1","Receptor, Endothelin B","Endothelin Receptor Antagonists"],"keywords":["Thapsigargin","Extracellular","Phospholipase C","Intracellular","Receptor","Endocrinology","Fura-2","Internal medicine","Endothelin 1","Endoplasmic reticulum","Inositol","Chemistry","Receptor antagonist","EGTA","Antagonist","Biology","Cell biology","Calcium","Biochemistry","Medicine","Cytosol","Enzyme"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:43:40.623702Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}