{"doi":"10.1007/bf02973908","title":"Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells","abstract":null,"journal":"Archives of Pharmacal Research","year":2006,"id":640715,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1665287,"name":"Meihua Jin","orcid":null,"position":1,"is_corresponding":false},{"id":1665288,"name":"Eunkyung Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1665289,"name":"Tae Chul Moon","orcid":null,"position":3,"is_corresponding":false},{"id":1665293,"name":"Zhejiu Quan","orcid":null,"position":4,"is_corresponding":false},{"id":1665294,"name":"Ju Hye Yang","orcid":null,"position":5,"is_corresponding":false},{"id":1665295,"name":"Kun Ho Son","orcid":null,"position":6,"is_corresponding":false},{"id":1665296,"name":"Kil-Ung Kim","orcid":null,"position":7,"is_corresponding":false},{"id":1665297,"name":"Jong Kun Son","orcid":null,"position":8,"is_corresponding":false},{"id":1665298,"name":"Hyeun Wook Chang","orcid":null,"position":9,"is_corresponding":false},{"id":1665286,"name":"Se Jong Kim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells","abstract":"Methyl gallate (MG) is a medicinal herbal product that is isolated from Paeonia lactiflora that inhibits cyclooxygenase-2 (COX-2) dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with an IC50 values of 17.0 microM. This compound also found inhibited the COX-2-dependent conversion of the exogenous arachidonic acid to PGD2 in a dose-dependent manner with an IC50 values of 19.0 microM, using a COX enzyme assay kit. However, at concentrations up to 80 microM, MG did not inhibit COX-2 protein expression in BMMC, indicating that MG inhibits COX-2 activity directly. Furthermore, MG consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 5.3 microM. These results demonstrate that MG has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity, which might provide the basis for novel anti-inflammatory drugs.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17121182","pmcid":null,"openalex_id":"https://openalex.org/W2045126023","authors":[],"funders":[],"total_grants":0,"fwci":0.3079,"citation_percentile":0.56986032,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":3},{"year":2015,"count":4},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":5},{"year":2025,"count":3}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF02973908.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF02973908/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF02973908","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf02973908","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17121182","host_type":"repository"}],"fields_of_study":["Mast cells and histamine","Inflammatory mediators and NSAID effects","Quinazolinone synthesis and applications","Animals","Arachidonate 5-Lipoxygenase","Arachidonic Acid","Bone Marrow Cells","Cell Line, Tumor","Cyclooxygenase 2","Cyclooxygenase Inhibitors","Dose-Response Relationship, Drug","Enzyme Inhibitors","Gallic Acid","Interleukin-10","Leukotriene C4","Lipopolysaccharides","Male","Mast Cells","Mice","Mice, Inbred BALB C","Molecular Structure","Paeonia","Plant Extracts","Plant Leaves","Plant Stems","Prostaglandin D2","Stem Cell Factor"],"mesh_terms":["Animals","Arachidonate 5-Lipoxygenase","Bone Marrow Cells","Dose-Response Relationship, Drug","Enzyme Inhibitors","Gallic Acid","Lipopolysaccharides","Male","Mast Cells","Mice, Inbred BALB C","Plant Extracts","Prostaglandin D2","Molecular Structure","Arachidonic Acid","Interleukin-10","Cyclooxygenase Inhibitors","Leukotriene C4","Plant Leaves","Plant Stems","Stem Cell Factor","Paeonia","Cell Line, Tumor","Mice","Cyclooxygenase 2"],"keywords":["Cyclooxygenase","Arachidonate 5-lipoxygenase","Prostaglandin D2","Arachidonic acid","Chemistry","IC50","Leukotriene C4","Lipoxygenase","Pharmacology","Methyl gallate","Prostaglandin E2","Bone marrow","Enzyme","Biochemistry","Prostaglandin","Prostaglandin E","Leukotriene","In vitro","Biology","Immunology","Endocrinology","Antioxidant"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T13:21:46.830200Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}