{"doi":"10.1007/bf02892573","title":"Changes in cyclic nucleotide levels and phosphodiesterase and protein kinase activities in mitogenically stimulated 3T3 fibroblasts","abstract":null,"journal":"Virchows Archiv B Cell Pathology Including Molecular Pathology","year":1981,"id":658043,"datarank":0.2921322250764151,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.050716538211300025,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.050716538211300025,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1687095,"name":"J. F. Kuo","orcid":null,"position":1,"is_corresponding":false},{"id":1717793,"name":"K. Norrby","orcid":null,"position":2,"is_corresponding":false},{"id":1717795,"name":"J. Wikberg","orcid":null,"position":3,"is_corresponding":false},{"id":1717792,"name":"R. G. G. Andersson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Changes in cyclic nucleotide levels and phosphodiesterase and protein kinase activities in mitogenically stimulated 3T3 fibroblasts","abstract":"Activities of cyclic-nucleotide-hydrolysing enzymes cAMP-, cCMP- and cGMP phosphodiesterase, the intracellular concentrations of cAMP, cCMP, and cGMP, and the activity of the cAMP-dependent protein kinase were studied in serum-starved 3T3 cells stimulated to proliferate by serum. Within 1 and 2 min after stimulation the activities of cAMP- and cGMP phosphodiesterase were unaffected while the concentration of cGMP was raised and that of cAMP lowered, suggesting increased synthesis of cGMP and simultaneously reduced synthesis of cAMP. 48 h after stimulation, when the cells multiplied rapidly, both the cAMP phosphodiesterase and the cCMP phosphodiesterase were reduced. Evidence was also obtained that cAMP-dependent protein kinase is important for expressing the cAMP effect in the 3T3 cells.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6117970","pmcid":null,"openalex_id":"https://openalex.org/W2007897250","authors":[],"funders":[],"total_grants":0,"fwci":0.5618,"citation_percentile":0.61380546,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF02892573.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF02892573/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF02892573","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf02892573","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6117970","host_type":"repository"}],"fields_of_study":["Phosphodiesterase function and regulation","Enzyme function and inhibition","Nitric Oxide and Endothelin Effects","Animals","Cattle","Cyclic AMP","Cyclic CMP","Cyclic GMP","Fibroblasts","Mitogens","Nucleotides, Cyclic","Phosphoric Diester Hydrolases","Protein Kinases","Time Factors"],"mesh_terms":["Cyclic AMP","Animals","Cattle","Cyclic CMP","Fibroblasts","Cyclic GMP","Mitogens","Nucleotides, Cyclic","Phosphoric Diester Hydrolases","Protein Kinases","Time Factors"],"keywords":["Phosphodiesterase","PDE10A","Phosphodiesterase 3","Protein kinase A","Stimulation","Intracellular","Cyclic nucleotide","Internal medicine","Cyclic nucleotide phosphodiesterase","Endocrinology","Biology","3T3 cells","Phosphodiesterase inhibitor","Kinase","cGMP-dependent protein kinase","Enzyme","Nucleotide","Cell biology","Biochemistry","Mitogen-activated protein kinase kinase","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T03:08:36.092934Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}