{"doi":"10.1007/bf02510476","title":"U3 snoRNA may recycle through different compartments of the nucleolus","abstract":null,"journal":"Chromosoma","year":1997,"id":47327,"datarank":1.262664205435585,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.7990078374318376,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.7990078374318376,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":18,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":218770,"name":"Anton Borovjagin","orcid":null,"position":1,"is_corresponding":false},{"id":172868,"name":"Susan A. Gerbi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"U3 snoRNA may recycle through different compartments of the nucleolus","abstract":"A model is proposed in which U3 small nucleolar RNA (snoRNA) is recruited from an inactive, stored form in the dense fibrillar component (DFC) of the nucleolus to an active form that is associated with the initial ribosomal RNA (rRNA) precursor. The initial steps of rRNA processing occur in the DFC, and then it is proposed that the U3 snoRNA moves with intermediates in rRNA processing from the DFC to the granular component (GC) of the nucleolus. The nucleolar protein fibrillarin is located primarily in the DFC, and it is suggested that the complex of fibrillarin and U3 snoRNA dissociates when U3 snoRNA transits to the GC. Finally, when U3 snoRNA is released from the processed rRNA, the tether holding the rRNA in the nucleolus is broken and rRNA can then be exported from the nucleolus to the cytoplasm. U3 snoRNA is hypothesized to recycle back from the GC to the DFC where it is stored until future association with another initial rRNA precursor. Data supporting this model are summarized. U3 snoRNA is also stored in the coiled body of interphase cells and in the nucleolar remnants and prenucleolar bodies of mitotic cells, and there may be some similarity in the binding sites for stored U3 snoRNA in the DFC and in these structures.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9211967","pmcid":null,"openalex_id":"https://openalex.org/W1989221817","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM 20261","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM020261-13","title":"FINE STRUCTURE OF RIBOSOMAL RNA"}],"total_grants":2,"fwci":0.3546,"citation_percentile":0.5558566,"influential_citations":3,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2016,"count":2},{"year":2018,"count":1},{"year":2021,"count":1},{"year":2022,"count":1}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF02510476.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF02510476/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF02510476","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf02510476","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9211967","host_type":"repository"},{"url":"https://doi.org/10.1007/s004120050201","host_type":""},{"url":"https://dx.doi.org/10.1007/bf02510476","host_type":""}],"fields_of_study":["RNA modifications and cancer","RNA Research and Splicing","RNA regulation and disease","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Cell Cycle","Cell Nucleolus","Humans","Models, Genetic","RNA Precursors","RNA Processing, Post-Transcriptional","RNA, Ribosomal","RNA, Small Nuclear"],"mesh_terms":["Animals","Cell Cycle","Cell Nucleolus","Humans","Models, Genetic","RNA Precursors","RNA Processing, Post-Transcriptional","RNA, Ribosomal","RNA, Small Nuclear"],"keywords":["Fibrillarin","Small nucleolar RNA","Nucleolus","Ribosomal RNA","Biology","RNA","Cell biology","Nucleolus organizer region","Cytoplasm","Genetics","Non-coding RNA","Gene","Models, Genetic","RNA, Ribosomal","RNA, Small Nuclear","Cell Cycle","RNA Precursors","Animals","Humans","RNA Processing, Post-Transcriptional","Cell Nucleolus"],"sdg_mappings":[{"sdg_number":12,"sdg_label":"12. 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