{"doi":"10.1007/bf02460597","title":"Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model","abstract":null,"journal":"Bulletin of Mathematical Biology","year":1996,"id":603594,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1548389,"name":"Meghan A. Burke","orcid":null,"position":1,"is_corresponding":false},{"id":1548391,"name":"Jayant Kalagnanam","orcid":null,"position":2,"is_corresponding":false},{"id":1548392,"name":"Susan A. McCarthy","orcid":null,"position":3,"is_corresponding":false},{"id":235092,"name":"David J. Tweardy","orcid":"0000-0001-8492-8460","position":4,"is_corresponding":false},{"id":550768,"name":"Penelope A. Morel","orcid":"0000-0002-1743-3676","position":5,"is_corresponding":false},{"id":1548387,"name":"Benoît F. Morel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model","abstract":"The cytokines are the information superhighway of the immune system. They are an important component of the integrated behavior of the system. In order to be able to have a good understanding of the immune system, we must be able to model the effect of cytokines and their combined effect. This work is a step in that direction. We study the combined effect of two cytokines: interleukin-2 (IL-2) and interleukin-4 (IL-4) on some cells of the immune system. Interleukin-2 and interleukin-4 are important growth and differentiation factors for B and T cells. Interleukin-4 antagonizes the effect of interleukin-2 on B cells and some T cells while it synergizes with interleukin-2 on other T cells. We build a mathematical model of the interaction of both cytokines on T and B cells as a building block toward a model of the Th1/Th2 cross-regulation. The response of a given cell to the combination of interleukin-2 and interleukin-4 is shown to involve competing dynamical effects which can lead to either antagonistic or synergistic combined effect.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8688839","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI31427","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF02460597.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF02460597/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF02460597","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Lymphocytes","Animals","Humans","Receptors, Interleukin","Receptors, Interleukin-2","Receptors, Interleukin-4","Antigens, CD","Interleukin-2","Interleukin-4","Cell Division","Drug Interactions","Mathematics","Models, Biological","In Vitro Techniques"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:19:25.977054Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}