{"doi":"10.1007/bf02172073","title":"Comparison between crude Interleukin-2 and recombinant Interleukin-2 in maintaining killing activity of cultured lymphocytes","abstract":null,"journal":"Biotherapy","year":1990,"id":613721,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1581183,"name":"Norimichi Kan","orcid":null,"position":1,"is_corresponding":false},{"id":1581186,"name":"Takashi Okino","orcid":null,"position":2,"is_corresponding":false},{"id":1552442,"name":"Kohei Satoh","orcid":null,"position":3,"is_corresponding":false},{"id":1581193,"name":"Keiichi Mise","orcid":null,"position":4,"is_corresponding":false},{"id":1581199,"name":"Yasufumi Teramura","orcid":null,"position":5,"is_corresponding":false},{"id":1581202,"name":"Seiji Yamasaki","orcid":null,"position":6,"is_corresponding":false},{"id":1581206,"name":"Kazuhisa Ohgaki","orcid":null,"position":7,"is_corresponding":false},{"id":1581208,"name":"Takayoshi Tobe","orcid":null,"position":8,"is_corresponding":false},{"id":525333,"name":"Masaki Nakanishi","orcid":"0000-0003-0415-072X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison between crude Interleukin-2 and recombinant Interleukin-2 in maintaining killing activity of cultured lymphocytes","abstract":"Peripheral blood lymphocytes, regional lymph node lymphocytes or malignant effusion lymphocytes from cancer patients were incubated with crude IL-2 (cIL-2) for 13 days. These effectors, which frequently expressed IL-2 receptor (IL-2R), proliferated well and possessed augmented killing activity against fresh autologous tumor cells and K562. However, when recombinant IL-2 (rIL-2) was added for the last 4 days of culture instead of cIL-2, IL-2R expression and killing activity against fresh autologous tumor cells decreased significantly (P less than 0.05). Phenotypic analysis indicated that cIL-2 significantly promoted the expansion of the cytotoxic population (CD8+.11b-)(P less than 0.05). The decreases in killing activity and IL-2R expression were restored by 0.004% PHA plus rIL-2, but not in the presence of rIFN-gamma, rIL-1 alpha, rIL-1 beta, rIL-4 or rIL-6. PHA-free cIL-2 maintained killing activity, but not IL-2R expression. We conclude that some factors in cIL-2 and a low dose of PHA-P are necessary for the maintenance of killing activity and IL-2R expression of cultured lymphocytes in the late phase of culture.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2119201","pmcid":null,"openalex_id":"https://openalex.org/W2071018827","authors":[],"funders":[],"total_grants":0,"fwci":1.3992,"citation_percentile":0.81831478,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF02172073.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF02172073/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF02172073","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf02172073","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2119201","host_type":"repository"}],"fields_of_study":["Immune Cell Function and Interaction","Cell Division","Cell Survival","Cytotoxicity, Immunologic","Humans","Interferon-gamma","Interleukin-2","Leukocyte Count","Lymphocyte Activation","Lymphocytes","Phytohemagglutinins","Recombinant Proteins","T-Lymphocytes, Cytotoxic","Tumor Cells, Cultured"],"mesh_terms":["Cell Division","Cell Survival","Cytotoxicity, Immunologic","Humans","Interferon-gamma","Interleukin-2","Leukocyte Count","Lymphocyte Activation","Lymphocytes","Phytohemagglutinins","Recombinant Proteins","T-Lymphocytes, Cytotoxic","Tumor Cells, Cultured"],"keywords":["Recombinant DNA","Interleukin 2","Interleukin","Interleukin 1β","Interleukin 11","Interleukin 4","Immunology","Biology","Microbiology","Chemistry","Cytokine","Biochemistry","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T09:02:19.759296Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}