{"doi":"10.1007/bf01228296","title":"Serum glibenclamide in diabetic patients, and influence of food on the kinetics and effects of glibenclamide","abstract":null,"journal":"Diabetologia","year":1980,"id":673980,"datarank":0.6846522287201755,"base_score":4.564348191467836,"endowment":4.564348191467836,"self_citation_contribution":0.6846522287201755,"citation_network_contribution":0.0,"self_endowment_contribution":0.6846522287201755,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":95,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1760940,"name":"A. Melander","orcid":null,"position":1,"is_corresponding":false},{"id":1760941,"name":"B. Scherst�n","orcid":null,"position":2,"is_corresponding":false},{"id":1760943,"name":"E. W�hlin-Boll","orcid":null,"position":3,"is_corresponding":false},{"id":1760939,"name":"G. Sartor","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Serum glibenclamide in diabetic patients, and influence of food on the kinetics and effects of glibenclamide","abstract":"The steady state concentrations of glibenclamide in serum were measured radioimmunologically in 37 diabetic patients after administration for at least a year. No other antidiabetic drugs had been given. The interindividual variation in glibenclamide concentrations was extremely large (0 to 1520 nmol/l), greatly exceeding the variation in dosage (2.5--25 mg daily). There was no relation between dose and serum concentration of glibenclamide. Only four (9%) patients had fasting blood glucose concentrations below 5.5 mmol/l, and fewer than half had values below 8 mmol/l. In most cases, therefore, the therapy was inadequate. Single-dose kinetics of glibenclamide was assessed in healthy volunteers. Food intake did not influence the bioavailability of a 5 mg dose of glibenclamide. There was no insulin increase in response to glibenclamide unless a meal was also given, and this increase was not significant until 1 h after administration of drug and meal, when the mean serum concentration of glibenclamide had reached 100 nmol/l. Even in the fasting state, however, there was a progressive fall in blood glucose after glibenclamide administration, significant within 45 min and with a nadir at 2--2 1/2 h.","is_dataset_classified":null,"base_score":4.564348191467836,"endowment":4.564348191467836,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6767639","pmcid":null,"openalex_id":"https://openalex.org/W2165858836","authors":[],"funders":[],"total_grants":0,"fwci":10.3645,"citation_percentile":0.98345124,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/BF01228296.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/BF01228296.pdf","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF01228296.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF01228296/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF01228296","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf01228296","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6767639","host_type":"repository"}],"fields_of_study":["Pancreatic function and diabetes","Diabetes Treatment and Management","Diabetes Management and Research"],"mesh_terms":["Adult","Aged","Blood Glucose","Diabetes Mellitus","Dose-Response Relationship, Drug","Eating","Glyburide","Humans","Insulin","Kinetics","Male","Middle Aged","Reference Values"],"keywords":["Glibenclamide","Internal medicine","Medicine","Endocrinology","Diabetes mellitus","Meal","Bioavailability","Insulin","Pharmacokinetics","Oral administration","Pharmacology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T15:07:33.256812Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}