{"doi":"10.1007/bf01172874","title":"Possible interrelationship between gluconeogenesis and ketogenesis in the liver","abstract":"<jats:p>Effeects of various ketogenic substrates on gluconeogenesis from lactate were examined. D,L-3-Hydroxybutyrate (5 mM) stimulated gluconeogenesis by 41%, the effect being the same as that of 5 mM acetate (49%). No stimulating effect of acetoacetate was observed; conversely, acetoacetate (up to 40 mM) partially or completely abolished the observed stimulating effects of acetate, oleate, and 3-hydroxybutyrate. The results suggest that, in intact liver cells, pyruvate is transported into mitochondria in exchange for acetoacetate and that an interrelationship between gluconeogenesis and ketogenesis at the level of mitochondrial pyruvate carrier may exist in the liver.</jats:p>","journal":"Bioscience Reports","year":1983,"id":604513,"datarank":0.3120148508549869,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.10407069668700333,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.10407069668700333,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551051,"name":"Ladislav Kümmel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Possible interrelationship between gluconeogenesis and ketogenesis in the liver","abstract":"<jats:p>Effeects of various ketogenic substrates on gluconeogenesis from lactate were examined. D,L-3-Hydroxybutyrate (5 mM) stimulated gluconeogenesis by 41%, the effect being the same as that of 5 mM acetate (49%). No stimulating effect of acetoacetate was observed; conversely, acetoacetate (up to 40 mM) partially or completely abolished the observed stimulating effects of acetate, oleate, and 3-hydroxybutyrate. The results suggest that, in intact liver cells, pyruvate is transported into mitochondria in exchange for acetoacetate and that an interrelationship between gluconeogenesis and ketogenesis at the level of mitochondrial pyruvate carrier may exist in the liver.</jats:p>","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6626706","pmcid":null,"openalex_id":"https://openalex.org/W2035434794","authors":[],"funders":[],"total_grants":0,"fwci":0.3037,"citation_percentile":0.54514406,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://portlandpress.com/bioscirep/article-pdf/3/7/643/470885/bsr0030643.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf01172874","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6626706","host_type":"repository"}],"fields_of_study":["Diet and metabolism studies","Metabolism, Diabetes, and Cancer","Adipose Tissue and Metabolism","3-Hydroxybutyric Acid","Acetates","Acetoacetates","Animals","Gluconeogenesis","Hydroxybutyrates","Ketones","Lactates","Male","Mitochondria, Liver","Oleic Acids","Pyruvates","Rats","Rats, Inbred Strains"],"mesh_terms":["Acetates","Acetoacetates","Animals","Gluconeogenesis","Hydroxybutyrates","Ketones","Lactates","Male","Mitochondria, Liver","Oleic Acids","Pyruvates","Rats, Inbred Strains","3-Hydroxybutyric Acid","Rats"],"keywords":["Ketogenesis","Gluconeogenesis","Chemistry","Ketone bodies","Internal medicine","Endocrinology","Biochemistry","Glycolysis","Metabolism","Biology","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:18:36.938489Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}