{"doi":"10.1007/bf00731505","title":"Blood group glycosphingolipid expression in kidney of an individual with the rare blood group A1 Le(a?b+) p phenotype: absence of blood group structures based on the globoseries","abstract":null,"journal":"Glycoconjugate Journal","year":1996,"id":644757,"datarank":0.25627626503954526,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.014860578174430173,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.014860578174430173,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1678408,"name":"Per-�ke Jovall","orcid":null,"position":1,"is_corresponding":false},{"id":1678409,"name":"Sohbat Ghardashkani","orcid":null,"position":2,"is_corresponding":false},{"id":1678410,"name":"Bo E. Samuelsson","orcid":null,"position":3,"is_corresponding":false},{"id":1678411,"name":"Michael E. Breimer","orcid":null,"position":4,"is_corresponding":false},{"id":1678407,"name":"Karin Lindstr�m","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Blood group glycosphingolipid expression in kidney of an individual with the rare blood group A1 Le(a?b+) p phenotype: absence of blood group structures based on the globoseries","abstract":"Total neutral glycolipid fractions were isolated from kidney and ureter tissue obtained at autopsy of an individual of the rare blood group A1 Le(a-b+) p. The amount of glycolipids isolated were 3.7 and 2.5 mg g-1 dry tissue weight for the kidney and ureter tissue, which is in the range of reference blood group P kidneys. Part of the kidney glycolipid fraction was subfractionated by HPLC. Glycolipid compounds were structurally characterized by thin-layer chromatography (chemical detection and immunostaining with monoclonal antibodies), proton NMR spectroscopy and mass spectrometry. Globotriaosyl- and globotetraosyl-ceramides, which are the major compounds in kidneys of P individuals, were absent in the p kidney, and a comparatively increased amount of monoglycosyl- and lactosylceramides was found. A shift to longer fatty acyl chains in the ceramide part of lactosylceramides was noted. Elongated globoseries compounds with five to seven sugar residues, including the blood group A type 4 chain structure, were lacking. A slight increase in neolactotetraosyl- and blood group X pentaglycosyl-ceramides was noticed. The study confirms an enzymatic block in the conversion of lactosylceramide to elongated globoseries compounds in the kidney tissue similar to that of erythrocytes of p individuals.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8737255","pmcid":null,"openalex_id":"https://openalex.org/W2073050143","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.12866828,"influential_citations":0,"citation_trend":[{"year":2013,"count":2}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF00731505.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF00731505/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF00731505","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf00731505","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8737255","host_type":"repository"}],"fields_of_study":["Erythrocyte Function and Pathophysiology","Glycosylation and Glycoproteins Research","Blood groups and transfusion"],"mesh_terms":["Animals","Antibodies, Monoclonal","Antibody Specificity","Blood Group Antigens","Chromatography, High Pressure Liquid","Chromatography, Thin Layer","Female","Globosides","Glycolipids","Glycosphingolipids","Humans","Kidney","Magnetic Resonance Spectroscopy","P Blood-Group System","Phenotype","Mass Spectrometry","Ureter","Mice"],"keywords":["Glycolipid","Lactosylceramide","Glycosphingolipid","Ceramide","Kidney","Chemistry","Ganglioside","Immunostaining","Biochemistry","Globotriaosylceramide","Molecular biology","Internal medicine","Biology","Immunohistochemistry","Endocrinology","Immunology","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T02:01:17.677152Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}