{"doi":"10.1007/bf00274931","title":"The pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27","abstract":null,"journal":"Rheumatology International","year":1992,"id":687359,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":10759,"name":"D. Yu","orcid":"0000-0001-5921-5231","position":1,"is_corresponding":false},{"id":1795682,"name":"H. Kellner","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27","abstract":"The association of HLA-B27 and seronegative spondyloarthropathies, especially ankylosing spondylitis has been known for almost two decades. The spontaneous development of spondyloarthropathy like joint disease in HLA-B27 transgenic rats verifies the suspicion that the HLA-B27 antigens are directly responsible for disease development. With the recently revealed crystal structure of HLA-B27 and understanding of the class I molecule in general, a new hypothesis can be formulated based on the assumption that the pathogenesis of these diseases is a subversion of the physiological function.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1439478","pmcid":null,"openalex_id":"https://openalex.org/W2036462248","authors":[],"funders":[],"total_grants":0,"fwci":2.1856,"citation_percentile":0.8671665,"influential_citations":0,"citation_trend":[{"year":2012,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF00274931.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF00274931/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF00274931","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf00274931","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1439478","host_type":"repository"}],"fields_of_study":["Spondyloarthritis Studies and Treatments","Psoriasis: Treatment and Pathogenesis","Dermatology and Skin Diseases","Amino Acid Sequence","Animals","Chemical Phenomena","Chemistry","HLA-B27 Antigen","Humans","Joint Diseases","Molecular Sequence Data"],"mesh_terms":["Amino Acid Sequence","Animals","Chemistry","Humans","Joint Diseases","Molecular Sequence Data","HLA-B27 Antigen","Chemical Phenomena"],"keywords":["Spondyloarthropathy","Ankylosing spondylitis","HLA-B27","Medicine","Sacroiliitis","Human leukocyte antigen","Disease","Immunology","Pathogenesis","Spondylarthropathies","Spondylitis","Antigen","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T21:50:30.845722Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}