{"doi":"10.1007/bf00187929","title":"Distribution of p75 and trk-neurotrophin receptor proteins in adult human sympathetic ganglia","abstract":null,"journal":"Anatomy and Embryology","year":1996,"id":649769,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1693992,"name":"F.J. Naves","orcid":null,"position":1,"is_corresponding":false},{"id":1693993,"name":"M.E. Valle","orcid":null,"position":2,"is_corresponding":false},{"id":1693994,"name":"I. Esteban","orcid":null,"position":3,"is_corresponding":false},{"id":1693995,"name":"E. Bronzetti","orcid":null,"position":4,"is_corresponding":false},{"id":1693996,"name":"E. Vazquez","orcid":null,"position":5,"is_corresponding":false},{"id":1693997,"name":"J.A. Vega","orcid":null,"position":6,"is_corresponding":false},{"id":1693991,"name":"O. Garcia-Suarez","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Distribution of p75 and trk-neurotrophin receptor proteins in adult human sympathetic ganglia","abstract":"We investigated the expression of immunoreactivity (IR) for low- (p75) and high-affinity (trk proteins) neurotrophin-receptor proteins in adult human paravertebral-sympathetic ganglion neurons. Mouse monoclonal antibodies against the pan-neurotrophin-receptor p75, and rabbit polyclonal antibodies against specific epitopes of the intracytoplasmic domain on trk neurotrophin-receptor proteins were used in fresh unfixed and formaldehyde-fixed paraffin-embedded sympathetic ganglia. All adult human paravertebral-sympathetic neurons displayed trkA neurotrophin-receptor-like protein IR, 10% express trkC neurotrophin-receptor-like protein IR, 37-44% show p75 IR, and no IR was obtained for trkB neurotrophin-receptor-like protein. The intensity of immunostaining was independent of the neuron size. Labelling of non-neuronal tissues, especially blood-vessel walls, was observed for p75, trkA and trkC neurotrophin-receptor proteins. These results indicate that overlapping exists in the expression of p75 and trk neurotrophin-receptor proteins in adult human paravertebral-sympathetic neurons, and suggest that neurotrophins might act on these neurons.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8737813","pmcid":null,"openalex_id":"https://openalex.org/W2046594903","authors":[],"funders":[],"total_grants":0,"fwci":0.6236,"citation_percentile":0.61389937,"influential_citations":0,"citation_trend":[{"year":2013,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF00187929.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF00187929/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF00187929","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf00187929","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8737813","host_type":"repository"}],"fields_of_study":["Nerve injury and regeneration","Signaling Pathways in Disease","Neuropeptides and Animal Physiology"],"mesh_terms":["Adult","Age Factors","Antibody Specificity","Female","Ganglia, Sympathetic","Humans","Male","Middle Aged","Neurons","Receptors, Nerve Growth Factor","Receptor Protein-Tyrosine Kinases","Receptor, Nerve Growth Factor","Receptor, Ciliary Neurotrophic Factor","Receptor, trkC","Receptor, trkA"],"keywords":["Trk receptor","Neurotrophin","Tropomyosin receptor kinase A","Low-affinity nerve growth factor receptor","Tropomyosin receptor kinase C","Tropomyosin receptor kinase B","Biology","Neurotrophin-3","Cell biology","Receptor","Molecular biology","Neurotrophic factors","Brain-derived neurotrophic factor","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:17:55.497862Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}