{"doi":"10.1007/bf00178598","title":"Does the VP1 gene of foot-and-mouth disease virus behave as a molecular clock?","abstract":null,"journal":"Journal of Molecular Evolution","year":1992,"id":626571,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1620824,"name":"Fernando Gonz�lez-Candelas","orcid":null,"position":1,"is_corresponding":false},{"id":1620827,"name":"Andr�s Moya","orcid":null,"position":2,"is_corresponding":false},{"id":1620820,"name":"SantiagoF. Elena","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Does the VP1 gene of foot-and-mouth disease virus behave as a molecular clock?","abstract":"We have carried out a phylogenetic study of the evolution of the VP1 gene sequence from different serological types and subtypes of foot-and-mouth disease virus (FMDV). The maximum-likelihood method developed by Hasegawa and co-workers (Hasegawa et al. 1985) for the estimation of evolutionary parameters and branching dates has been used to decide between alternative models of evolution: constant versus variable rates. The results obtained indicate that a constant rate model, i.e., a molecular clock, seems to be the most plausible one. However, additional information suggests the possibility that the appearance of serotype CS has been accompanied by an episode of rapid evolution (Villaverde et al. 1991). We discuss the possibility that this evolution of RNA viruses was due to episodic positive Darwinian selection, which would have helped the new variant to escape the immunogenic pressure from the hosts.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1325567","pmcid":null,"openalex_id":"https://openalex.org/W2021610274","authors":[],"funders":[],"total_grants":0,"fwci":1.1416,"citation_percentile":0.73215401,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/BF00178598.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/BF00178598/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/BF00178598","host_type":"publisher"},{"url":"https://doi.org/10.1007/bf00178598","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1325567","host_type":"repository"}],"fields_of_study":["Animal Disease Management and Epidemiology","Viral Infections and Immunology Research","Viral Infectious Diseases and Gene Expression in Insects"],"mesh_terms":["Base Sequence","Capsid","Biological Evolution","Aphthovirus","Genes, Viral","Molecular Sequence Data","Phylogeny","Statistics as Topic","Capsid Proteins"],"keywords":["Biology","Molecular clock","Phylogenetic tree","Foot-and-mouth disease virus","Molecular evolution","Viral evolution","Evolutionary biology","Natural selection","Rate of evolution","Phylogenetics","Gene","Positive selection","Genetics","Virus","Virology","Selection (genetic algorithm)","RNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T14:22:15.918691Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}