{"doi":"10.1007/978-981-33-6044-0_12","title":"Genetic Architecture of Depression: Where Do We Stand Now?","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2021,"id":589948,"datarank":0.34065648020202194,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.02874024895004651,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.02874024895004651,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1509448,"name":"Orkun Aydin","orcid":null,"position":1,"is_corresponding":false},{"id":1509449,"name":"Ayla Arslan","orcid":null,"position":2,"is_corresponding":false},{"id":1509447,"name":"Pinar Unal-Aydin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genetic Architecture of Depression: Where Do We Stand Now?","abstract":"The research of depression genetics has been occupied by historical candidate genes which were tested by candidate gene association studies. However, these studies were mostly not replicable. Thus, genetics of depression have remained elusive for a long time. As research moves from candidate gene association studies to GWAS, the hypothesis-free non-candidate gene association studies in genome-wide level, this trend will likely change. Despite the fact that the earlier GWAS of depression were not successful, the recent GWAS suggest robust findings for depression genetics. These altogether will catalyze a new wave of multidisciplinary research to pin down the neurobiology of depression.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33834402","pmcid":null,"openalex_id":"https://openalex.org/W3132065130","authors":[],"funders":[],"total_grants":0,"fwci":8.8239,"citation_percentile":0.97421019,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2024,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/978-981-33-6044-0_12","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-981-33-6044-0_12","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33834402","host_type":"repository"}],"fields_of_study":["Genetic Associations and Epidemiology","Cognitive Abilities and Testing","Genetics and Neurodevelopmental Disorders","Depression","Genetic Predisposition to Disease","Genome-Wide Association Study","Humans","Polymorphism, Single Nucleotide"],"mesh_terms":["Depression","Humans","Genetic Predisposition to Disease","Polymorphism, Single Nucleotide","Genome-Wide Association Study"],"keywords":["Genome-wide association study","Candidate gene","Depression (economics)","Genetic architecture","Genetic association","Genetics","Biology","Gene","Psychology","Single-nucleotide polymorphism","Quantitative trait locus","Genotype","Depression","Gwas","Candidate Genes","Association Studies","Depression Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T11:26:57.779537Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}