{"doi":"10.1007/978-981-13-1286-1_2","title":"POMC Neurons: Feeding, Energy Metabolism, and Beyond","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2018,"id":647035,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":824241,"name":"Cheng Zhan","orcid":"0000-0001-8745-9276","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"POMC Neurons: Feeding, Energy Metabolism, and Beyond","abstract":"The central melanocortin system is a well-established neuronal pathway involved in regulating energy metabolism. Pro-opiomelanocortin (POMC) neurons, agouti gene-related protein (AgRP) neurons, and their downstream cells expressing the melanocortin-3 (MC3R) and melanocortin-4 receptors (MC4R) are three key components of the central melanocortin pathway. This chapter focuses on the Pomc gene and the POMC neural system. First, I summarize the established role of this system in inhibiting food intake. Second, in light of new cutting-edge techniques, our understanding of how POMC neurons function to regulate energy homeostasis has been refined during the last few years. I describe some recent advances and discuss bidirectional effects of POMC neurons on feeding. Finally, the physiological significance beyond energy metabolism, in particular for reward and sex, is also discussed.","is_dataset_classified":null,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30390283","pmcid":null,"openalex_id":"https://openalex.org/W2898991672","authors":[],"funders":[],"total_grants":0,"fwci":5.5054,"citation_percentile":0.96896552,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":8},{"year":2022,"count":6},{"year":2023,"count":10},{"year":2024,"count":17},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-981-13-1286-1_2","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-981-13-1286-1_2","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30390283","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Biochemical Analysis and Sensing Techniques","Adipose Tissue and Metabolism","Biology","Medicine"],"mesh_terms":["Eating","Energy Metabolism","Feeding Behavior","Homeostasis","Humans","Neurons","Pro-Opiomelanocortin"],"keywords":["Melanocortin","Energy homeostasis","Melanocortin 3 receptor","Biology","Neuroscience","Energy metabolism","Homeostasis","Melanocortin 4 receptor","Receptor","Cell biology","Endocrinology","Melanocortin receptor","Genetics","Feeding behavior","Arcuate nucleus","Nucleus tractus solitarius","α-MSH","Reward","Β-endorphin","Pomc Neurons"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.26689979.v1","title":"Additional file 5 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.26689976.v1","title":"Additional file 4 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.26689976","title":"Additional file 4 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25358015","title":"Additional file 2 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.26689973.v1","title":"Additional file 3 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.26689973","title":"Additional file 3 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25357866","title":"Additional file 1 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25358015.v1","title":"Additional file 2 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.26689979","title":"Additional file 5 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25357866.v1","title":"Additional file 1 of Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1","publisher":"figshare","resource_type":"Image"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T16:20:50.214863Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}