{"doi":"10.1007/978-981-10-1061-3_3","title":"Extracellular Microvesicles (ExMVs) in Cell to Cell Communication: A Role of Telocytes","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2016,"id":590537,"datarank":1.688562438493323,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":1.1429245145343652,"self_endowment_contribution":0.5456379239589579,"citer_contribution":1.1429245145343652,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":36,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1510931,"name":"Daniel Ratajczak","orcid":null,"position":1,"is_corresponding":false},{"id":1510932,"name":"Daniel Pedziwiatr","orcid":null,"position":2,"is_corresponding":false},{"id":235299,"name":"Mariusz Z. Ratajczak","orcid":"0000-0002-0071-0198","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Extracellular Microvesicles (ExMVs) in Cell to Cell Communication: A Role of Telocytes","abstract":"There are several mechanisms by which cells communicate with each other. Evidence accumulates that the evolutionary oldest mechanisms of cell-cell communication involves extracellular microvesicles (ExMVs). Generally, these circular membrane fragments enriched for mRNA, miRNA, proteins, and bioactive lipids are released by exocytosis from endosomal compartment or are directly formed by budding from cell surface membranes. ExMVs from endosomal compartment called exosomes are smaller in size ~100 nM as compared to larger ones released from cell membranes that are in size up to 1 μM. In this chapter we will present an emerging link between ExMVs and recently identified novel cell-cell communication network involving a new type of cell known as telocyte. Mounting evidence accumulates that telocytes mediate several of their biological effects in several organs by releasing ExMVs enriched in mRNA, miRNA, proteins, and several biological mediators to the target cells.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27796879","pmcid":null,"openalex_id":"https://openalex.org/W2545003596","authors":[],"funders":[{"funder_name":"NIH HHS","grant_id":"2R01 DK074720","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL112788","title":null}],"total_grants":2,"fwci":6.6731,"citation_percentile":0.97234438,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":5},{"year":2025,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-981-10-1061-3_3","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-981-10-1061-3_3","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27796879","host_type":"repository"}],"fields_of_study":["Extracellular vesicles in disease","MicroRNA in disease regulation","RNA Interference and Gene Delivery","Animals","Cell Communication","Cell Differentiation","Cell Membrane","Extracellular Vesicles","Gene Expression Regulation","Humans","Induced Pluripotent Stem Cells","MicroRNAs","Particle Size","Proteins","RNA, Messenger","Signal Transduction","Telocytes"],"mesh_terms":["Extracellular Vesicles","Telocytes","Animals","Cell Communication","Cell Differentiation","Cell Membrane","Gene Expression Regulation","Humans","Particle Size","Proteins","RNA, Messenger","Signal Transduction","MicroRNAs","Induced Pluripotent Stem Cells"],"keywords":["Microvesicles","Cell biology","Endosome","Cell","Exocytosis","Extracellular","Cell type","Biology","Compartment (ship)","Cell membrane","Microvesicle","Cell signaling","microRNA","Intracellular","Chemistry","Signal transduction","Membrane","Biochemistry","Gene","Exosomes","Cell-cell Communication","Telocytes","Ectosomes","Multivesicular Cargo","Extracellular Microvesicles (Exmvs)","Horizontal Transfer Of Mrna","Membrane Lipid Rafts"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T01:13:06.353021Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}