{"doi":"10.1007/978-94-017-7555-7_5","title":"Oncolytic Immunotherapy for Treatment of Cancer","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2016,"id":654141,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1707132,"name":"X. N. Miao","orcid":null,"position":1,"is_corresponding":false},{"id":1707133,"name":"C. M. Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1707134,"name":"D. C. Yu","orcid":null,"position":3,"is_corresponding":false},{"id":1707131,"name":"A. Tsun","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Oncolytic Immunotherapy for Treatment of Cancer","abstract":"Immunotherapy entails the treatment of disease by modulation of the immune system. As detailed in the previous chapters, the different modes of achieving immune modulation are many, including the use of small/large molecules, cellular therapy, and radiation. Oncolytic viruses that can specifically attack, replicate within, and destroy tumors represent one of the most promising classes of agents for cancer immunotherapy (recently termed as oncolytic immunotherapy). The notion of oncolytic immunotherapy is considered as the way in which virus-induced tumor cell death (known as immunogenic cancer cell death (ICD)) allows the immune system to recognize tumor cells and provide long-lasting antitumor immunity. Both immune responses toward the virus and ICD together contribute toward successful antitumor efficacy. What is now becoming increasingly clear is that monotherapies, through any of the modalities detailed in this book, are neither sufficient in eradicating tumors nor in providing long-lasting antitumor immune responses and that combination therapies may deliver enhanced efficacy. After the rise of the genetic engineering era, it has been possible to engineer viruses to harbor combination-like characteristics to enhance their potency in cancer immunotherapy. This chapter provides a historical background on oncolytic virotherapy and its future application in cancer immunotherapy, especially as a combination therapy with other treatment modalities.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27240460","pmcid":null,"openalex_id":"https://openalex.org/W2418354553","authors":[],"funders":[],"total_grants":0,"fwci":7.701,"citation_percentile":0.9660655,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-94-017-7555-7_5","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-94-017-7555-7_5","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27240460","host_type":"repository"}],"fields_of_study":["Virus-based gene therapy research","CAR-T cell therapy research","Cancer Research and Treatments","Antineoplastic Agents","Combined Modality Therapy","Gamma Rays","Gene Expression Regulation, Neoplastic","Genetic Therapy","Humans","Immunity, Innate","Immunomodulation","Immunotherapy","Neoplasm Proteins","Neoplasms","Oncolytic Virotherapy","Oncolytic Viruses","Signal Transduction","Virus Replication"],"mesh_terms":["Antineoplastic Agents","Combined Modality Therapy","Gamma Rays","Humans","Immunity, Innate","Immunotherapy","Neoplasm Proteins","Neoplasms","Virus Replication","Genetic Therapy","Signal Transduction","Gene Expression Regulation, Neoplastic","Oncolytic Virotherapy","Oncolytic Viruses","Immunomodulation"],"keywords":["Oncolytic virus","Immunotherapy","Virotherapy","Immune system","Cancer immunotherapy","Medicine","Cancer","Immunology","Cancer research","Internal medicine","Combination therapy","Immuno-oncology","Oncolytic Immunotherapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.26602549.v1","title":"Additional file 1 of Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26602549","title":"Additional file 1 of Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T04:08:52.137707Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}