{"doi":"10.1007/978-3-7091-6499-0_25","title":"Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine","abstract":null,"journal":"Journal of Neural Transmission. Supplement","year":1998,"id":673397,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1759403,"name":"K. F. Tipton","orcid":null,"position":1,"is_corresponding":false},{"id":1759405,"name":"G. A. Lyles","orcid":null,"position":2,"is_corresponding":false},{"id":1759402,"name":"D. H. Fitzgerald","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine","abstract":"The possibility that increased levels of the activity of the semicarbazide-sensitive amine oxidase (SSAO) might, to some extent, compensate for the loss of monoamine oxidase (MAO) activity in the atypical form of Norrie Disease, was examined using the rat as a model. Long-term treatment with the MAO inhibitor tranylcypromine (1 mg/kg/day) resulted in sustained inhibition of MAO-A and MAO-B activities in liver and brain. After one week, the SSAO activity in heart had increased by 79% above the control levels. This increase was maintained for 3 weeks. Since such alterations might result from enzyme induction, the turnover of the enzyme was studied in cultured cells from rat aortic smooth muscle. The time-course of recovery of enzyme activity following irreversible inhibition by MDL 72145 corresponded to a half-life of approximately 6 days for this process.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9564625","pmcid":null,"openalex_id":"https://openalex.org/W21385414","authors":[],"funders":[],"total_grants":0,"fwci":0.4758,"citation_percentile":0.63787848,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-3-7091-6499-0_25","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-3-7091-6499-0_25","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9564625","host_type":"repository"}],"fields_of_study":["Microbial metabolism and enzyme function","Allylamine","Amine Oxidase (Copper-Containing)","Animals","Aorta","Brain","Cells, Cultured","Female","Isoenzymes","Liver","Male","Monoamine Oxidase","Monoamine Oxidase Inhibitors","Muscle, Smooth, Vascular","Myocardium","Rats","Rats, Sprague-Dawley","Time Factors","Tranylcypromine"],"mesh_terms":["Allylamine","Animals","Aorta","Brain","Cells, Cultured","Female","Amine Oxidase (Copper-Containing)","Isoenzymes","Liver","Male","Monoamine Oxidase","Monoamine Oxidase Inhibitors","Muscle, Smooth, Vascular","Myocardium","Time Factors","Tranylcypromine","Rats, Sprague-Dawley","Rats"],"keywords":["Tranylcypromine","Monoamine oxidase","Semicarbazide","Chemistry","Enzyme","Pharmacology","Enzyme assay","Endocrinology","Biochemistry","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T13:18:29.577526Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}