{"doi":"10.1007/978-3-319-75402-4_40","title":"Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2018,"id":655348,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1196275,"name":"Ichiro Masai","orcid":"0000-0002-6626-6595","position":1,"is_corresponding":false},{"id":1710697,"name":"Maria Iribarne","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?","abstract":"Humans with mutations in the phototransduction pathway develop forms of retinal degeneration, such as retinitis pigmentosa, cone dystrophy, or Leber congenital amaurosis. Similarly, numerous phototransduction mutant animal models resemble retinal degeneration. In our lab, using a zebrafish model, we study cone-specific phototransduction mutants. cGMP is the second messenger in the phototransduction pathway, and abnormal cGMP levels are associated with photoreceptor death. Rd1, a rod-specific phosphodiesterase 6 (Pde6) subunit mutant in mice, is one of the most widely used animal models for retinal degeneration. Rd1 mutant mice accumulate cGMP, causing rapid photoreceptor degeneration. However, much less is known about photoreceptor mutants producing abnormally low levels of cGMP. Here, focusing on Pde6 mutants in zebrafish and mice, we propose a correlation between cGMP levels and speed of photoreceptor degeneration.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29721960","pmcid":null,"openalex_id":"https://openalex.org/W2803047688","authors":[],"funders":[],"total_grants":0,"fwci":1.9867,"citation_percentile":0.85404198,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2021,"count":3},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-3-319-75402-4_40","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-3-319-75402-4_40","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29721960","host_type":"repository"}],"fields_of_study":["Retinal Development and Disorders","Retinal Diseases and Treatments","Photoreceptor and optogenetics research","Animals","Color Vision Defects","Cyclic GMP","Cyclic Nucleotide Phosphodiesterases, Type 6","Disease Models, Animal","Eye Proteins","Forecasting","Humans","Light Signal Transduction","Photoreceptor Cells, Vertebrate","Retinal Degeneration","Zebrafish","Zebrafish Proteins"],"mesh_terms":["Animals","Color Vision Defects","Disease Models, Animal","Eye Proteins","Forecasting","Cyclic GMP","Humans","Retinal Degeneration","Zebrafish","Photoreceptor Cells, Vertebrate","Zebrafish Proteins","Cyclic Nucleotide Phosphodiesterases, Type 6","Light Signal Transduction"],"keywords":["Visual phototransduction","Retinal degeneration","Retinitis pigmentosa","Zebrafish","Retina","Degeneration (medical)","Phosphodiesterase","Mutant","Biology","Cell biology","Rhodopsin","Retinal","Transducin","Neuroscience","Genetics","Medicine","Ophthalmology","Biochemistry","Gene","Mouse","cGMP","Photoreceptor Degeneration","Pde6","Rapid Degeneration","Slow Degeneration"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T10:34:06.194333Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}