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Penick","orcid":null,"position":1,"is_corresponding":false},{"id":328633,"name":"Jean F. Welter","orcid":"0000-0002-1040-7918","position":2,"is_corresponding":false},{"id":1586094,"name":"Luis A. Solchaga","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells: Tips and Tricks","abstract":"It is well known that adult cartilage lacks the ability to repair itself; this makes articular cartilage a very attractive target for tissue engineering. The majority of articular cartilage repair models attempt to deliver or recruit reparative cells to the site of injury. A number of efforts are directed to the characterization of progenitor cells and the understanding of the mechanisms involved in their chondrogenic differentiation. Our laboratory has focused on cartilage repair using mesenchymal stem cells and studied their differentiation into cartilage. Mesenchymal stem cells are attractive candidates for cartilage repair due to their osteogenic and chondrogenic potential, ease of harvest, and ease of expansion in culture. However, the need for chondrogenic differentiation is superposed on other technical issues associated with cartilage repair; this adds a level of complexity over using mature chondrocytes. This chapter will focus on the methods involved in the isolation and expansion of human mesenchymal stem cells, their differentiation along the chondrogenic lineage, and the qualitative and quantitative assessment of chondrogenic differentiation.","is_dataset_classified":null,"base_score":5.438079308923196,"endowment":5.438079308923196,"datacite_reuse_total":8,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21431525","pmcid":null,"openalex_id":"https://openalex.org/W101350248","authors":[],"funders":[],"total_grants":0,"fwci":38.5734,"citation_percentile":0.99804688,"influential_citations":0,"citation_trend":[{"year":2012,"count":11},{"year":2013,"count":5},{"year":2014,"count":8},{"year":2015,"count":16},{"year":2016,"count":17},{"year":2017,"count":17},{"year":2018,"count":17},{"year":2019,"count":20},{"year":2020,"count":16},{"year":2021,"count":20},{"year":2022,"count":15},{"year":2023,"count":17},{"year":2024,"count":31},{"year":2025,"count":11},{"year":2026,"count":6}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3106977","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3106977","host_type":"repository"},{"url":"http://link.springer.com/content/pdf/10.1007/978-1-60761-999-4_20.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-60761-999-4_20","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21431525","host_type":"repository"}],"fields_of_study":["Osteoarthritis Treatment and Mechanisms","Mesenchymal stem cell research","Silk-based biomaterials and applications"],"mesh_terms":["Bone Marrow Cells","Cell Differentiation","Cell Separation","Humans","Quality Control","RNA","Cryopreservation","Cell Culture Techniques","Chondrogenesis","Mesenchymal Stem Cells"],"keywords":["Chondrogenesis","Mesenchymal stem cell","Cartilage","Cell biology","Stem cell transplantation for articular cartilage repair","Progenitor cell","Stem cell","Articular cartilage repair","Regeneration (biology)","Cellular differentiation","Biology","Chemistry","Anatomy","Adult stem cell","Medicine","Pathology","Articular cartilage","Osteoarthritis","Genetics"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.22614614.v1","title":"Additional file 1 of Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22614614","title":"Additional file 1 of Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25853158","title":"Additional file 2 of Decellularization and enzymatic preconditioning of bovine uterus for improved recellularization","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25852979","title":"Additional file 1 of Decellularization and enzymatic preconditioning of bovine uterus for improved recellularization","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25852979.v1","title":"Additional file 1 of Decellularization and enzymatic preconditioning of bovine uterus for improved recellularization","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.25853158.v1","title":"Additional file 2 of Decellularization and enzymatic preconditioning of bovine uterus for improved recellularization","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.22614617.v1","title":"Additional file 2 of Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.22614617","title":"Additional file 2 of Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T19:48:56.172250Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}