{"doi":"10.1007/978-1-60327-815-7_23","title":"Visualization of DNA Replication Sites in Mammalian Nuclei","abstract":null,"journal":"Methods in Molecular Biology","year":2009,"id":682655,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1783394,"name":"Daniela S. Dimitrova","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Visualization of DNA Replication Sites in Mammalian Nuclei","abstract":"DNA replication takes place at discrete sites in the cell nucleus, named replication foci. The spatial arrangements of these foci change in the course of S phase in a temporally regulated and reproducible fashion forming five distinct and highly conserved replication patterns. The organization of nuclear replication sites can be studied by electron and light microscopy techniques. This chapter describes several procedures for detection of replication foci in mammalian nuclei via indirect immunofluorescence microscopy.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19563120","pmcid":null,"openalex_id":"https://openalex.org/W2420068704","authors":[],"funders":[],"total_grants":0,"fwci":0.9128,"citation_percentile":0.77581491,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-1-60327-815-7_23.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-60327-815-7_23","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19563120","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","DNA and Nucleic Acid Chemistry","Epigenetics and DNA Methylation","Cell Membrane Permeability","Cell Nucleus","DNA Replication","Deoxyribonucleotides","Fluorescent Antibody Technique, Indirect","Fluorescent Dyes","HeLa Cells","Humans","Microscopy, Fluorescence","Nuclear Proteins","S Phase","Staining and Labeling"],"mesh_terms":["Cell Membrane Permeability","Cell Nucleus","Deoxyribonucleotides","DNA Replication","Fluorescent Dyes","HeLa Cells","Humans","Microscopy, Fluorescence","Nuclear Proteins","Staining and Labeling","S Phase","Fluorescent Antibody Technique, Indirect","Hela Cells"],"keywords":["Replication (statistics)","Origin recognition complex","Control of chromosome duplication","DNA replication","Eukaryotic DNA replication","Biology","Cell biology","S phase","DNA","Nucleus","Replication timing","Licensing factor","Pre-replication complex","Replication factor C","Genetics","Virology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T21:00:06.637171Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}