{"doi":"10.1007/978-1-4939-6875-6_20","title":"ABC-Transporter Mediated Sterol Export from Cells Using Radiolabeled Sterols","abstract":null,"journal":"Methods in Molecular Biology","year":2017,"id":618526,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1595728,"name":"Ingrid C. Gelissen","orcid":null,"position":1,"is_corresponding":false},{"id":1595727,"name":"Alryel Yang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"ABC-Transporter Mediated Sterol Export from Cells Using Radiolabeled Sterols","abstract":"Cholesterol export from cells to extracellular acceptors represents the first step of the reverse cholesterol transport process and is an essential part of the multifaceted pathway for cells to control their cholesterol levels. Malfunction of this pathway leads to cholesterol accumulation in cells such as macrophages, which can form the basis of conditions like atherosclerosis. A number of ATP-binding cassette (ABC) transporters, namely ABCA1, ABCA7, ABCG1, and ABCG4, play an essential role in this process. In this chapter, we describe methods utilizing radiolabeled sterols for measuring ABC-transporter mediated sterol export, utilizing endogenously expressed transporters as well as overexpression systems.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28205181","pmcid":null,"openalex_id":"https://openalex.org/W2589122947","authors":[],"funders":[],"total_grants":0,"fwci":16.8997,"citation_percentile":0.98990251,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-1-4939-6875-6_20","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-4939-6875-6_20","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28205181","host_type":"repository"}],"fields_of_study":["Cholesterol and Lipid Metabolism","Drug Transport and Resistance Mechanisms","Peroxisome Proliferator-Activated Receptors","ATP-Binding Cassette Transporters","Animals","Atherosclerosis","Biological Transport, Active","CHO Cells","Cholesterol","Cricetulus","Humans","Isotope Labeling","THP-1 Cells"],"mesh_terms":["THP-1 Cells","Animals","Biological Transport, Active","Cholesterol","Cricetulus","Humans","Isotope Labeling","CHO Cells","ATP-Binding Cassette Transporters","Atherosclerosis"],"keywords":["ABCA1","ATP-binding cassette transporter","ABCG1","Sterol","Transporter","Cholesterol","Chemistry","Biochemistry","Extracellular","Cell biology","Sterol regulatory element-binding protein","Reverse cholesterol transport","Biology","Gene","Lipoprotein","Abc-transporter","Abca7","Abcg4","Cholesterol Export"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T04:38:21.242434Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}