{"doi":"10.1007/978-1-4615-0135-0_20","title":"Kynurenine Metabolism in Central Nervous System in Experimental Chronic Renal Failure","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2003,"id":599580,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1536647,"name":"Dariusz Pawlak","orcid":null,"position":1,"is_corresponding":false},{"id":1536649,"name":"Anna Tankiewicz","orcid":null,"position":2,"is_corresponding":false},{"id":1536651,"name":"Ewa Chabielska","orcid":null,"position":3,"is_corresponding":false},{"id":1536653,"name":"Wlodzimierz Buczko","orcid":null,"position":4,"is_corresponding":false},{"id":1536645,"name":"Joanna Topczewska-Bruns","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Kynurenine Metabolism in Central Nervous System in Experimental Chronic Renal Failure","abstract":"Tryptophan metablolism via kynureninc pathway leads to the formation of several neuroactive substances including kynurenine, anthranilic acid and quinolinic acid, which are involved in numerous neurodegenerative diseases. Also chronic renal insufficiency is associated with neurological disturbances but it is still not clear which substances are responsible for those disorders. Thus, the aim of our study was to evaluate the concentration of tryptophan, kynurenine and anthranilic acid in plasma as well as in different brain regions in uremic rats. We have shown that tryptophan concentrations in plasma and in brain were decreased, whereas kynurenine and anthranilic acid levels were elevated, both in plasma and in central nervous system. Only in cerebellum and hippocampus were no difference in concentration of antranilic acid between control and uremic rats. Accumulation of tryptophan metabolites in nervous tissue may be involved in pathogenesis of several neurological disorders in uremia.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15206730","pmcid":null,"openalex_id":"https://openalex.org/W120802899","authors":[],"funders":[],"total_grants":0,"fwci":0.6957,"citation_percentile":0.64556962,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2016,"count":3},{"year":2019,"count":1},{"year":2021,"count":3},{"year":2022,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-1-4615-0135-0_20","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-4615-0135-0_20","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15206730","host_type":"repository"}],"fields_of_study":["Tryptophan and brain disorders","Bipolar Disorder and Treatment","Pharmacological Effects and Toxicity Studies","Animals","Central Nervous System","Central Nervous System Diseases","Kidney Failure, Chronic","Kynurenine","Male","Rats","Rats, Wistar","Tissue Distribution","Tryptophan","ortho-Aminobenzoates"],"mesh_terms":["Animals","Central Nervous System","Central Nervous System Diseases","Kidney Failure, Chronic","Kynurenine","Male","Tissue Distribution","Tryptophan","Rats, Wistar","Rats","ortho-Aminobenzoates"],"keywords":["Quinolinic acid","Kynurenine","Kynurenine pathway","Anthranilic acid","Uremia","Tryptophan","Central nervous system","Kynurenic acid","Endocrinology","Chemistry","Internal medicine","Medicine","Biochemistry","Amino acid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T10:43:53.110292Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}