{"doi":"10.1007/978-1-4614-0899-4_2","title":"The Role of Adams in Notch Signaling","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2012,"id":688522,"datarank":0.692268077526189,"base_score":4.61512051684126,"endowment":4.61512051684126,"self_citation_contribution":0.692268077526189,"citation_network_contribution":0.0,"self_endowment_contribution":0.692268077526189,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":100,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1798747,"name":"Marc A. Vooijs","orcid":null,"position":1,"is_corresponding":false},{"id":1798746,"name":"Arjan J. Groot","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Role of Adams in Notch Signaling","abstract":"Regulated intramembrane proteolysis (RIP) is a highly conserved signaling paradigm whereby membrane-bound signaling proteins are cleaved in their transmembrane region and then released into the cytoplasm to act as signaling molecules. In most if not all cases intramembrane cleavage is preceded and regulated by a membrane proximal cleavage step called 'ectodomain shedding'. Here we will review the role of ectodomain shedding in RIP of the NOTCH signaling pathway, a highly conserved cell-cell communication pathway that mediates cell fate decisions during development and in adult tissues.","is_dataset_classified":null,"base_score":4.61512051684126,"endowment":4.61512051684126,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22399336","pmcid":null,"openalex_id":"https://openalex.org/W57402234","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"208259","title":null}],"total_grants":1,"fwci":7.3942,"citation_percentile":0.97323004,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":7},{"year":2017,"count":5},{"year":2018,"count":6},{"year":2019,"count":5},{"year":2020,"count":8},{"year":2021,"count":19},{"year":2022,"count":13},{"year":2023,"count":8},{"year":2024,"count":6},{"year":2025,"count":7},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-1-4614-0899-4_2.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-4614-0899-4_2","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22399336","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4050497","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Cell Adhesion Molecules Research","Cancer-related gene regulation","ADAM Proteins","Adult","Cell Communication","Humans","Receptors, Notch","Signal Transduction"],"mesh_terms":["Adult","Cell Communication","Humans","Signal Transduction","ADAM Proteins","Receptors, Notch"],"keywords":["Ectodomain","Cell biology","Notch signaling pathway","Cytoplasm","Transmembrane protein","Signal transduction","Cell signaling","Hes3 signaling axis","Cleavage (geology)","Biology","Cell","Cell fate determination","Cell membrane","Notch proteins","Chemistry","Biochemistry","Receptor","Transcription factor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T17:05:01.001139Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}