{"doi":"10.1007/978-1-4419-7823-3_10","title":"Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression","abstract":null,"journal":"Advances in Experimental Medicine and Biology","year":2010,"id":645798,"datarank":0.6937459219926407,"base_score":4.624972813284271,"endowment":4.624972813284271,"self_citation_contribution":0.6937459219926407,"citation_network_contribution":0.0,"self_endowment_contribution":0.6937459219926407,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":171283,"name":"Witold Filipowicz","orcid":null,"position":1,"is_corresponding":false},{"id":1681745,"name":"Nicole-Claudia Meisner","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression","abstract":"Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional levels. One of the most important sites of control involves mRNA 3' untranslated regions (3'utrs), which are recognized by RNA-binding proteins (RBPs) and microRNAs (miRNAs). These factors greatly influence translational efficiency and stability of target mRNAs and often also determine their cellular localization. HuR, a ubiquitously expressed member of the ElaV family of RBPs, has been implicated in regulation of stability and translation of over one hundred mRNAs in mammalian cells. Recent data indicate that some of the effects of HuR can be explained by its interplay with miRNAs. Binding of HuR may suppress the inhibitory effect of mirNAs interacting with the 3'UTR and redirect the repressed mRNA to polysomes for active translation. However, HuR can also synergize with miRNAs. The finding that HuR is able to disengage miRNAs from the repressed mrNa, or render them inactive, provides evidence that miRNa regulation is much more dynamic then originally anticipated. In this chapter we review properties of HuR and describe examples of the cross-talk between the protein and miRNAs, with emphasis on response of the regulation to cellular stress.","is_dataset_classified":null,"base_score":4.624972813284271,"endowment":4.624972813284271,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21755477","pmcid":null,"openalex_id":"https://openalex.org/W35524438","authors":[],"funders":[],"total_grants":0,"fwci":15.0287,"citation_percentile":0.99084354,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":14},{"year":2014,"count":7},{"year":2015,"count":11},{"year":2016,"count":11},{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":12},{"year":2020,"count":6},{"year":2021,"count":4},{"year":2023,"count":5},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/978-1-4419-7823-3_10.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-4419-7823-3_10","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21627034","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21755477","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","RNA and protein synthesis mechanisms"],"mesh_terms":["ELAV-Like Protein 1","Animals","Antigens, Surface","Gene Expression Regulation","Humans","Repressor Proteins","Genes, myc","RNA-Binding Proteins","MicroRNAs","ELAV Proteins","RNA, Messenger","3' Untranslated Regions"],"keywords":["microRNA","Translational regulation","Translation (biology)","RNA-binding protein","Three prime untranslated region","Polysome","Psychological repression","Untranslated region","Messenger RNA","AU-rich element","Biology","Post-transcriptional regulation","Cell biology","Regulation of gene expression","Stress granule","P-bodies","Gene expression","RNA","Gene","Genetics","Ribosome"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T10:10:54.874020Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}