{"doi":"10.1007/978-1-0716-2655-9_7","title":"Modeling Alzheimer’s Disease Using Human Brain Organoids","abstract":null,"journal":"Methods in Molecular Biology","year":2023,"id":608608,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1563289,"name":"Mariana Holubiec","orcid":null,"position":1,"is_corresponding":false},{"id":1563290,"name":"Livia Goto-Silva","orcid":null,"position":2,"is_corresponding":false},{"id":1563291,"name":"Ivan Fernandez Bessone","orcid":null,"position":3,"is_corresponding":false},{"id":1563292,"name":"Gabriela Vitória","orcid":null,"position":4,"is_corresponding":false},{"id":1244914,"name":"Beatriz Mello","orcid":"0000-0002-4511-2757","position":5,"is_corresponding":false},{"id":1563293,"name":"Matias Alloatti","orcid":null,"position":6,"is_corresponding":false},{"id":1563294,"name":"Bart Vanderborght","orcid":null,"position":7,"is_corresponding":false},{"id":477746,"name":"Tomás L. 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Brain organoids are three-dimensional cellular aggregates derived from induced pluripotent stem cells (iPSCs) that recreate different neural cell interactions and tissue characteristics in culture. Here, we describe the protocol for the generation of brain organoids derived from AD patients and for the analysis of AD-derived pathology. AD organoids can recapitulate beta-amyloid and tau pathological features, making them a promising model for studying the molecular mechanisms underlying disease and for in vitro drug testing.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36399268","pmcid":null,"openalex_id":"https://openalex.org/W4309491240","authors":[],"funders":[],"total_grants":0,"fwci":8.9891,"citation_percentile":0.98539488,"influential_citations":0,"citation_trend":[{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/978-1-0716-2655-9_7","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-0716-2655-9_7","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36399268","host_type":"repository"}],"fields_of_study":["Pluripotent Stem Cells Research","3D Printing in Biomedical Research","Neurogenesis and neuroplasticity mechanisms","Humans","Organoids","Alzheimer Disease","Brain","Amyloid beta-Peptides","Induced Pluripotent Stem Cells"],"mesh_terms":["Alzheimer Disease","Brain","Humans","Organoids","Amyloid beta-Peptides","Induced Pluripotent Stem Cells"],"keywords":["Induced pluripotent stem cell","Organoid","Neuroscience","Human brain","Disease","Drug development","Dementia","Drug discovery","Biology","Medicine","Bioinformatics","Drug","Pathology","Pharmacology","Embryonic stem cell","Amyloidosis","Neurodegenerative diseases","Alzheimer’s disease","Induced Pluripotent Stem Cells","Tauopathies","Brain Organoids"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T19:13:29.751333Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}