{"doi":"10.1007/978-1-0716-2265-0_4","title":"Integration of Engineered Delivery with the Pharmacokinetics of Medical Candidates via Physiology-Based Pharmacokinetics","abstract":null,"journal":"Methods in Molecular Biology","year":2022,"id":593262,"datarank":0.11090476749854492,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.006932690414553112,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.006932690414553112,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1140813,"name":"Xinyuan Zhang","orcid":"0000-0002-3372-0798","position":1,"is_corresponding":false},{"id":860229,"name":"Yuching Yang","orcid":"0000-0001-8982-4863","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Integration of Engineered Delivery with the Pharmacokinetics of Medical Candidates via Physiology-Based Pharmacokinetics.","abstract":"Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic computational model that can be used to predict a drug product's ADME (absorption, distribution, metabolism, and excretion) and pharmacokinetics (PK). In recent years, PBPK modeling and simulation has been used increasingly to address many biopharmaceutics and clinical pharmacology questions, such as the effect of formulations, intrinsic factors (age, organ dysfunction, etc.), and extrinsic factors (comedications, food) on the PK of an investigational drug product. In this chapter, we will briefly introduce various PBPK models for ADME prediction and general procedures for PBPK modeling and simulations. The readers are encouraged to read updated literature on new applications of PBPK modeling and simulation which is still an emerging area in pharmaceutical development.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35437718","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[],"fields_of_study":[],"mesh_terms":["Pharmaceutical Preparations","Pharmacology, Clinical","Pharmacokinetics","Biopharmaceutics","Models, Biological","Computer Simulation"],"keywords":["clinical pharmacology","Biopharmaceutics","Pharmaceutical Product Development","Adme (Absorption, Distribution, Metabolism, And Excretion)","Pbpk Modeling And Simulation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T18:05:19.824588Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}