{"doi":"10.1007/978-1-0716-0860-9_3","title":"Molecular Characterization of Testicular Germ Cell Tumors Using Tissue Microdissection","abstract":null,"journal":"Methods in Molecular Biology","year":2021,"id":689288,"datarank":0.5696940311641456,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.24011034456371264,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.24011034456371264,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1800711,"name":"Steven A. Mann","orcid":null,"position":1,"is_corresponding":false},{"id":1581853,"name":"Antonio Lopez-Beltran","orcid":null,"position":2,"is_corresponding":false},{"id":1800712,"name":"Michal Chovanec","orcid":null,"position":3,"is_corresponding":false},{"id":1508222,"name":"Matteo Santoni","orcid":null,"position":4,"is_corresponding":false},{"id":1766062,"name":"Mingsheng Wang","orcid":null,"position":5,"is_corresponding":false},{"id":459864,"name":"Costantine Albany","orcid":"0000-0002-9632-3802","position":6,"is_corresponding":false},{"id":323561,"name":"Nabil Adra","orcid":"0000-0001-8905-8329","position":7,"is_corresponding":false},{"id":1800713,"name":"Darrell D. Davidson","orcid":null,"position":8,"is_corresponding":false},{"id":1370037,"name":"Alessia Cimadamore","orcid":null,"position":9,"is_corresponding":false},{"id":1581850,"name":"Rodolfo Montironi","orcid":null,"position":10,"is_corresponding":false},{"id":1403939,"name":"Shaobo Zhang","orcid":"0000-0001-6965-1264","position":11,"is_corresponding":false},{"id":557737,"name":"Liang Cheng","orcid":"0000-0001-9214-0075","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Molecular Characterization of Testicular Germ Cell Tumors Using Tissue Microdissection","abstract":"Testicular germ cell tumors are among the most common malignancies seen in children and young adults. Genomic studies have identified characteristic molecular profiles in testicular cancer, which are associated with histologic subtypes and may predict clinical behavior including treatment responses. Emerging molecular technologies analyzing tumor genomics, transcriptomics, and proteomics may now guide precision management of testicular tumors. Laser-assisted microdissection methods such as laser capture microdissection efficiently isolate selected tumor cells from routine pathology specimens, avoiding contamination from nontarget cell populations. Laser capture microdissection in combination with next generation sequencing makes precise high throughput genetic evaluation effective and efficient. The use of laser capture microdissection (LCM) for molecular testing may translate into great benefits for the clinical management of patients with testicular cancers. This review discusses application protocols for laser-assisted microdissection to investigate testicular germ cell tumors.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32852755","pmcid":null,"openalex_id":"https://openalex.org/W3080792583","authors":[],"funders":[],"total_grants":0,"fwci":12.797,"citation_percentile":0.98573975,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":2}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/978-1-0716-0860-9_3","host_type":"publisher"},{"url":"https://doi.org/10.1007/978-1-0716-0860-9_3","host_type":"book series"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32852755","host_type":"repository"},{"url":"https://hdl.handle.net/11390/1243089","host_type":"repository"},{"url":"http://hdl.handle.net/11566/286257","host_type":"repository"}],"fields_of_study":["Testicular diseases and treatments","Cancer Genomics and Diagnostics","Molecular Biology Techniques and Applications","Biomarkers, Tumor","Clinical Decision-Making","Diagnosis, Differential","Disease Management","Disease Susceptibility","Humans","Immunohistochemistry","Male","Microdissection","Molecular Diagnostic Techniques","Neoplasms, Germ Cell and Embryonal","Testicular Neoplasms","Testicular Germ Cell Tumor"],"mesh_terms":["Clinical Decision-Making","Diagnosis, Differential","Disease Susceptibility","Humans","Immunohistochemistry","Male","Neoplasms, Germ Cell and Embryonal","Testicular Neoplasms","Biomarkers, Tumor","Disease Management","Molecular Diagnostic Techniques","Microdissection"],"keywords":["Microdissection","Laser capture microdissection","Germ cell","Biology","Computational biology","Proteomics","Pathology","Medicine","Gene","Gene expression","Genetics","Molecular genetics","Testicular Cancer","Tissue Microdissection","Germ Cell Tumors"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-20T06:29:41.210435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}