{"doi":"10.1007/82_2015_477","title":"Role of Calcium Signaling in B Cell Activation and Biology","abstract":"<jats:title>Abstract</jats:title>\n          <jats:p>Increase in intracellular levels of calcium ions (Ca<jats:sup>2+</jats:sup>) is one of the key triggering signals for the development of B cell response to the antigen. The diverse Ca<jats:sup>2+</jats:sup> signals finely controlled by multiple factors participate in the regulation of gene expression, B cell development, and effector functions. B cell receptor (BCR)-initiated Ca<jats:sup>2+</jats:sup> mobilization is sourced from two pathways: one is the release of Ca<jats:sup>2+</jats:sup> from the intracellular stores, endoplasmic reticulum (ER), and other is the prolonged influx of extracellular Ca<jats:sup>2+</jats:sup> induced by depleting the stores via store-operated calcium entry (SOCE) and calcium release-activated calcium (CRAC) channels. The identification of stromal interaction molecule 1(STIM1), the ER Ca<jats:sup>2+</jats:sup> sensor, and Orai1, a key subunit of the CRAC channel pore, has now provided the tools to understand the mode of Ca<jats:sup>2+</jats:sup> influx regulation and physiological relevance. Herein, we discuss our current understanding of the molecular mechanisms underlying BCR-triggered Ca<jats:sup>2+</jats:sup> signaling as well as its contribution to the B cell biological processes and diseases.</jats:p>","journal":"Current Topics in Microbiology and Immunology","year":2015,"id":23763,"datarank":2.5520329968901505,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":1.910533079037742,"self_endowment_contribution":0.6414999178524083,"citer_contribution":1.910533079037742,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":71,"citers_with_citation_signal":61,"citers_with_endowment":61,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":144720,"name":"Tomohiro Kurosaki","orcid":null,"position":1,"is_corresponding":false},{"id":144719,"name":"Yoshihiro Baba","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.276666119016055,"endowment":4.276666119016055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26369772","pmcid":null,"openalex_id":"https://openalex.org/W1655771988","authors":[],"funders":[],"total_grants":0,"fwci":10.168,"citation_percentile":0.97660819,"influential_citations":5,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":8},{"year":2019,"count":6},{"year":2020,"count":10},{"year":2021,"count":7},{"year":2022,"count":11},{"year":2023,"count":11},{"year":2024,"count":8},{"year":2025,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1007/82_2015_477","host_type":"book series"},{"url":"https://doi.org/10.1007/82_2015_477","host_type":"HYBRID"},{"url":"https://doi.org/10.1007/82_2015_477","host_type":"publisher"},{"url":"https://link.springer.com/content/pdf/10.1007/82_2015_477","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26369772","host_type":"repository"}],"fields_of_study":["Ion Channels and Receptors","Herbal Medicine Research Studies","Toxin Mechanisms and Immunotoxins","Biology","Medicine","Animals","B-Lymphocytes","Calcium","Calcium Channels","Calcium Signaling","Endoplasmic Reticulum","Humans"],"mesh_terms":["Animals","B-Lymphocytes","Calcium","Endoplasmic Reticulum","Humans","Calcium Channels","Calcium Signaling"],"keywords":["ORAI1","STIM1","Cell biology","Calcium signaling","Intracellular","Extracellular","Calcium","Endoplasmic reticulum","Calcium in biology","Signal transduction","Cell signaling","Biology","Plasma membrane Ca2+ ATPase","SERCA","Chemistry","Biochemistry","ATPase"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T20:27:31.428620Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}