{"doi":"10.1006/viro.1999.9695","title":"Immunogenicity, Genetic Stability, and Protective Efficacy of a Recombinant, Chimeric Yellow Fever-Japanese Encephalitis Virus (ChimeriVax-JE) as a Live, Attenuated Vaccine Candidate against Japanese Encephalitis","abstract":null,"journal":"Virology","year":1999,"id":589754,"datarank":7.2372393820245176,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"self_citation_contribution":0.7747178960885273,"citation_network_contribution":6.46252148593599,"self_endowment_contribution":0.7747178960885273,"citer_contribution":6.46252148593599,"corpus_percentile":null,"corpus_rank":null,"citation_count":174,"citer_count":141,"citers_with_citation_signal":123,"citers_with_endowment":123,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1508907,"name":"Z.-X. 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Guirakhoo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immunogenicity, Genetic Stability, and Protective Efficacy of a Recombinant, Chimeric Yellow Fever-Japanese Encephalitis Virus (ChimeriVax-JE) as a Live, Attenuated Vaccine Candidate against Japanese Encephalitis","abstract":"Yellow fever (YF) 17D vaccine virus, having a 60-year history of safe and effective use, is an ideal vector to deliver heterologous genes from other medically important flaviviruses. A chimeric YF/Japanese encephalitis (JE) virus (ChimeriVax-JE virus) was constructed by insertion of the premembrane and envelope (prME) genes of an attenuated human vaccine strain (SA14-14-2) of Japanese encephalitis (JE) virus between core and nonstructural (NS) genes of a YF 17D infectious clone. The virus grew to high titers in cell cultures and was not neurovirulent for 3- to 4-week-old mice at doses </=6 log10 plaque forming units (pfu) inoculated by the intracerebral (IC) route. In contrast, commercial YF 17D vaccine was highly neurovirulent for weanling mice by the same route. Mice inoculated subcutaneously with one dose of >/=10(3) pfu of ChimeriVax-JE virus were solidly protected against intraperitoneal challenge with a virulent JE virus. Genetic stability of the chimera was assessed by sequential passages in cell cultures or in mouse brain. All attenuating residues and the avirulent phenotype were preserved after 18 passages in cell cultures or 6 passages in mouse brains.","is_dataset_classified":null,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10329547","pmcid":null,"openalex_id":"https://openalex.org/W2004688624","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI36798-03","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R44AI036798-02","title":"JAPANESE ENCEPHALITIS VACCINE FROM MUTATED CDNA CLONE"}],"total_grants":2,"fwci":12.0141,"citation_percentile":0.98768473,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":12},{"year":2014,"count":11},{"year":2015,"count":3},{"year":2016,"count":7},{"year":2017,"count":8},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0042682299996952?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682299996952?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/viro.1999.9695","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10329547","host_type":"repository"},{"url":"http://dx.doi.org/10.1006/viro.1999.9695","host_type":""},{"url":"https://dx.doi.org/10.1006/viro.1999.9695","host_type":""}],"fields_of_study":["Mosquito-borne diseases and control","Vector-borne infectious diseases","Malaria Research and Control","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Brain","Cell Line","Chlorocebus aethiops","Disease Models, Animal","Encephalitis Virus, Japanese","Encephalitis, Japanese","Genes, Viral","Genetic Vectors","Humans","Macaca mulatta","Membrane Glycoproteins","Mice","Mice, Inbred C57BL","Mice, Inbred ICR","Recombination, Genetic","Sequence Analysis, DNA","Vaccines, Attenuated","Vaccines, DNA","Vero Cells","Viral Envelope Proteins","Viral Vaccines","Virus Replication","Yellow fever virus"],"mesh_terms":["Animals","Brain","Cell Line","Chlorocebus aethiops","Disease Models, Animal","Encephalitis Virus, Japanese","Encephalitis, Japanese","Genes, Viral","Genetic Vectors","Humans","Macaca mulatta","Membrane Glycoproteins","Mice, Inbred C57BL","Mice, Inbred ICR","Recombination, Genetic","Vaccines, Attenuated","Vero Cells","Viral Envelope Proteins","Viral Vaccines","Virus Replication","Yellow fever virus","Sequence Analysis, DNA","Vaccines, DNA","Mice"],"keywords":["Virology","Japanese encephalitis","Yellow fever","Biology","Virus","Immunogenicity","Japanese encephalitis vaccine","Attenuated vaccine","Flavivirus","Flaviviridae","Encephalitis","Recombinant virus","Viral encephalitis","Duck embryo vaccine","Vero cell","Yellow fever vaccine","Virulence","Recombinant DNA","Immune system","Gene","Immunology","Viral disease","Genetics","Encephalitis Virus, Japanese","Recombination, Genetic","Mice, Inbred ICR","Membrane Glycoproteins","Genes, Viral","Genetic Vectors","Brain","Sequence Analysis, DNA","Vaccines, Attenuated","Macaca mulatta","Cell Line","Mice, Inbred C57BL","Disease Models, Animal","Mice","Chlorocebus aethiops","Vaccines, DNA","Animals","Humans","Encephalitis, Japanese","Vero Cells"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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