{"doi":"10.1006/mcne.2001.1009","title":"Caspase Activity Is Involved in, but Is Dispensable for, Early Motoneuron Death in the Chick Embryo Cervical Spinal Cord","abstract":null,"journal":"Molecular and Cellular Neuroscience","year":2001,"id":604719,"datarank":2.1316662964585418,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":1.5541441562020328,"self_endowment_contribution":0.5775221402565088,"citer_contribution":1.5541441562020328,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":32,"citers_with_citation_signal":31,"citers_with_endowment":31,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551638,"name":"Nobuko Shiraiwa","orcid":null,"position":1,"is_corresponding":false},{"id":1551639,"name":"Takako Shimada","orcid":null,"position":2,"is_corresponding":false},{"id":1551640,"name":"Keiji Nishiyama","orcid":null,"position":3,"is_corresponding":false},{"id":289470,"name":"Jason Hong","orcid":"0000-0002-5062-8926","position":4,"is_corresponding":false},{"id":212927,"name":"Siwei Wang","orcid":null,"position":5,"is_corresponding":false},{"id":1551641,"name":"Takashi Momoi","orcid":null,"position":6,"is_corresponding":false},{"id":639022,"name":"Yasuo Uchiyama","orcid":"0000-0002-9104-533X","position":7,"is_corresponding":false},{"id":810596,"name":"Ronald W. 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When a more broad-spectrum caspase inhibitor was used (bocaspartyl (OMe)-fluoromethyl ketone, BAF), the appearance of degenerative changes in the cytoplasm was delayed by at least 12 h. However, following treatment with either Ac-DEVD-CHO or BAF for 24 h, the number of surviving healthy MNs did not differ from controls, indicating a normal occurrence of PCD despite the inhibition of caspases. These results suggest that caspase cascades that occur upstream of and are independent of the activation of caspase-3-like activity are responsible for the degenerative changes in the cytoplasm of dying cervical MNs. These data also suggest that, although one function of caspases may be to facilitate the kinetics of PCD, caspases are nonetheless dispensable for at least some forms of normal neuronal PCD in vivo.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11520178","pmcid":null,"openalex_id":"https://openalex.org/W2089173809","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"NS20402","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"08680808","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"10680704","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"","title":null}],"total_grants":4,"fwci":2.0121,"citation_percentile":0.86473051,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2017,"count":4},{"year":2019,"count":1},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1044743101910097?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1044743101910097?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/mcne.2001.1009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11520178","host_type":"repository"}],"fields_of_study":["Cell death mechanisms and regulation","Trace Elements in Health"],"mesh_terms":["Amino Acid Chloromethyl Ketones","Animals","Cervical Vertebrae","Chick Embryo","Coumarins","Dose-Response Relationship, Drug","Enzyme Inhibitors","Immunohistochemistry","Microscopy, Electron","Motor Neurons","Oligopeptides","Spinal Cord","Cysteine Proteinase Inhibitors","Apoptosis","Caspases","In Situ Nick-End Labeling","Caspase 3"],"keywords":["Caspase","Biology","Apoptosis","Programmed cell death","Cytoplasm","Caspase 3","Embryo","Cell biology","DNA fragmentation","Spinal cord","Caspase 2","Embryonic stem cell","Molecular biology","Neuroscience","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:47:19.610977Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}