{"doi":"10.1006/gyno.2001.6333","title":"A Noninvasive Reporter System to Image Adenoviral-Mediated Gene Transfer to Ovarian Cancer Xenografts","abstract":null,"journal":"Gynecologic Oncology","year":2001,"id":593907,"datarank":0.5897738449086489,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":0.0,"self_endowment_contribution":0.5897738449086489,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227900,"name":"Buck E. Rogers","orcid":"0000-0001-8189-1797","position":1,"is_corresponding":false},{"id":311559,"name":"Donald J. Buchsbaum","orcid":"0000-0003-2797-5847","position":2,"is_corresponding":false},{"id":367018,"name":"James M. Mountz","orcid":"0000-0001-8804-7257","position":3,"is_corresponding":false},{"id":378721,"name":"Kurt R. Zinn","orcid":"0000-0001-7463-4741","position":4,"is_corresponding":false},{"id":1520107,"name":"Tandra R. Chaudhuri","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Noninvasive Reporter System to Image Adenoviral-Mediated Gene Transfer to Ovarian Cancer Xenografts","abstract":"<h4>Objective</h4>Gene therapy trials for ovarian cancer would benefit from a noninvasive imaging modality to detect the location and extent of gene transfer. The human type 2 somatostatin receptor gene (hSSTr2) was evaluated as a reporter gene for imaging adenoviral (Ad) gene transfer to ovarian cancer.<h4>Methods</h4>A replication-incompetent Ad vector encoding hSSTr2 (Ad-hSSTr2) was used to infect SKOV3.ip1 cells in vitro and tumors growing in nude mice. Gamma camera imaging detected uptake of 99m-Tc-P2045 (a somatostatin analogue) due to expressed hSSTr2.<h4>Results</h4>Specific uptake of 99m-Tc-P2045 was imaged in Ad-hSSTr2-infected cells in vitro. Noninvasive in vivo imaging detected gene transfer to intraperitoneal tumors. Uptake of 99m-Tc-P2045 (percentage dose per gram of tumor) averaged 2.2 and 0.18 for Ad-hSSTr2-injected mice and controls, respectively.<h4>Conclusion</h4>This study reports the first noninvasive imaging method for imaging gene transfer to ovarian cancer. A human gene therapy trial is planned.","is_dataset_classified":null,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11606113","pmcid":null,"openalex_id":"https://openalex.org/W2081065484","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA83591-02","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA80104","title":null}],"total_grants":2,"fwci":3.2306,"citation_percentile":0.9182884,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":4},{"year":2014,"count":1},{"year":2016,"count":2},{"year":2018,"count":2},{"year":2020,"count":2},{"year":2022,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0090825801963334?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0090825801963334?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/gyno.2001.6333","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11606113","host_type":"repository"}],"fields_of_study":["Virus-based gene therapy research","Cancer Research and Treatments","Photodynamic Therapy Research Studies"],"mesh_terms":["Adenoviridae","Animals","Female","Genetic Vectors","Humans","Mice, Nude","Ovarian Neoplasms","Radionuclide Imaging","Organotechnetium Compounds","Receptors, Somatostatin","Genes, Reporter","Gene Transfer Techniques","Radiopharmaceuticals","Xenograft Model Antitumor Assays","Mice"],"keywords":["Ovarian cancer","Genetic enhancement","Reporter gene","Medicine","Gene transfer","In vivo","Cancer research","Cancer","Viral vector","In vitro","Somatostatin receptor","Gene","Pathology","Somatostatin","Biology","Gene expression","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T12:45:59.011852Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}