{"doi":"10.1006/geno.1994.1497","title":"Chromosome Mapping of the Human Arrestin (SAG), β-Arrestin 2 (ARRB2), and β-Adrenergic Receptor Kinase 2 (ADRBK2) Genes","abstract":null,"journal":"Genomics","year":1994,"id":652420,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":717686,"name":"Michele Sallese","orcid":"0000-0002-2555-3571","position":1,"is_corresponding":false},{"id":1701914,"name":"Anna Stornaiuolo","orcid":null,"position":2,"is_corresponding":false},{"id":1639640,"name":"Liborio Stuppia","orcid":null,"position":3,"is_corresponding":false},{"id":1701915,"name":"Giandomenico Palka","orcid":null,"position":4,"is_corresponding":false},{"id":1701916,"name":"Antonio De Blasi","orcid":null,"position":5,"is_corresponding":false},{"id":243297,"name":"Giuseppe Calabrese","orcid":"0000-0002-8846-4955","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chromosome Mapping of the Human Arrestin (SAG), β-Arrestin 2 (ARRB2), and β-Adrenergic Receptor Kinase 2 (ADRBK2) Genes","abstract":"Two types of proteins play a major role in determining homologous desensitization of G-coupled receptors: beta-adrenergic receptor kinase (beta ARK), which phosphorylates the agonist-occupied receptor and its functional cofactor, beta-arrestin. Both beta ARK and beta-arrestin are members of multigene families. The family of G-protein-coupled receptor kinases includes rhodopsin kinase, beta ARK1, beta ARK2, IT11-A (GRK4), GRK5, and GRK6. The arrestin/beta-arrestin gene family includes arrestin (also known as S-antigen), beta-arrestin 1, and beta-arrestin 2. Here we report the chromosome mapping of the human genes for arrestin (SAG), beta-arrestin 2 (ARRB2), and beta ARK2 (ADRBK2) by fluorescence in situ hybridization (FISH). FISH results confirmed the assignment of the gene coding for arrestin (SAG) to chromosome 2 and allowed us to refine its localization to band q37. The gene coding for beta-arrestin 2 (ARRB2) was mapped to chromosome 17p13 and that coding for beta ARK2 (ADRBK2) to chromosome 22q11.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7695743","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Telethon","grant_id":"E.0062","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0888754384714972?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0888754384714972?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Chromosomes, Human, Pair 2","Chromosomes, Human, Pair 17","Chromosomes, Human, Pair 22","Humans","Cyclic AMP-Dependent Protein Kinases","Eye Proteins","Arrestins","Arrestin","Antigens","In Situ Hybridization, Fluorescence","Chromosome Mapping","RNA Splicing","Gene Library","Genes","beta-Adrenergic Receptor Kinases","G-Protein-Coupled Receptor Kinase 3","beta-Arrestins","beta-Arrestin 1","beta-Arrestin 2"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T13:47:28.268815Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}