{"doi":"10.1006/expr.1996.0111","title":"Plasmodium chabaudi chabaudi:Differential Susceptibility of Gene-Targeted Mice Deficient in IL-10 to an Erythrocytic-Stage Infection","abstract":null,"journal":"Experimental Parasitology","year":1996,"id":685973,"datarank":0.6952093482344455,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":0.0,"self_endowment_contribution":0.6952093482344455,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":634035,"name":"Ralf Kühn","orcid":"0000-0003-1694-9803","position":1,"is_corresponding":false},{"id":1033238,"name":"Werner Müller","orcid":"0000-0002-1297-9725","position":2,"is_corresponding":false},{"id":1792204,"name":"Naveed Honarvar","orcid":null,"position":3,"is_corresponding":false},{"id":1792205,"name":"Ching Li","orcid":null,"position":4,"is_corresponding":false},{"id":586990,"name":"Jean Langhorne","orcid":"0000-0002-2257-9733","position":5,"is_corresponding":false},{"id":1792203,"name":"Andrea Linke","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Plasmodium chabaudi chabaudi:Differential Susceptibility of Gene-Targeted Mice Deficient in IL-10 to an Erythrocytic-Stage Infection","abstract":"Female and male mice deficient in IL-10 production by targeted disruption of the IL-10 gene were infected with Plasmodium chabaudi chabaudi (AS) blood-stage parasites. Both male and female mutant mice exhibited more severe signs of disease than did +/+ or heterozygous control mice. Female defective mice also displayed an increased mortality; 56% of mice died within 20 days of infection. Mortality did not appear to be due to a fulminating parasitemia as death occurred at different levels of parasitemia in the individual mice. The acute infection was accompanied by an enhanced Th1 IFN-gamma response. This response was retained in the chronic phase of infection of both male and female mutant mice, whereas in controls the responding CD4+ T cells were predominantly Th2 cells secreting IL-4. The data suggest that IL-10 regulates the inflammatory response to the parasite and that in its absence the combined effects of malaria toxins and the sustained or enhanced IFN-gamma response lead to increased pathology. In the case of female mice absence of IL-10 is sufficient to induce a lethal endotoxin-like reaction.","is_dataset_classified":null,"base_score":4.634728988229636,"endowment":4.634728988229636,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8932775","pmcid":null,"openalex_id":"https://openalex.org/W2040676910","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":1,"fwci":7.9356,"citation_percentile":0.97424501,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":7},{"year":2014,"count":5},{"year":2015,"count":5},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":6},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014489496901113?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014489496901113?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/expr.1996.0111","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8932775","host_type":"repository"},{"url":"https://edoc.mdc-berlin.de/14074/","host_type":"repository"},{"url":"https://research.manchester.ac.uk/en/publications/ec50fdcc-f9b7-40df-9e07-09c354293178","host_type":"repository"},{"url":"https://www.research.manchester.ac.uk/portal/en/publications/plasmodium-chabaudi-chabaudi-differential-susceptibility-of-genetargeted-mice-deficient-in-il10-to-an-erythrocyticstage-infection(ec50fdcc-f9b7-40df-9e07-09c354293178).html","host_type":"repository"}],"fields_of_study":["Malaria Research and Control","Coccidia and coccidiosis research","Vector-borne infectious diseases"],"mesh_terms":["Anemia","Animals","Disease Susceptibility","Erythrocytes","Female","Heterozygote","Interferon-gamma","Malaria","Male","Mice, Inbred C57BL","Spleen","CD4-Positive T-Lymphocytes","Interleukin-4","Interleukin-10","Plasmodium chabaudi","Mice, Knockout","Gene Targeting","Th1 Cells","Th2 Cells","Parasitemia","Mice"],"keywords":["Plasmodium chabaudi","Parasitemia","Biology","Immunology","Mutant","Ratón","Immunity","Gene","Immune system","Malaria","Genetics","Plasmodium falciparum"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T18:12:24.459715Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}