{"doi":"10.1006/exer.2001.1127","title":"Nicotinamide Prevents N -methyl- N -nitrosourea-induced Photoreceptor Cell Apoptosis in Sprague-Dawley Rats and C57BL Mice","abstract":null,"journal":"Experimental Eye Research","year":2002,"id":657620,"datarank":1.6162590272924309,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":1.0486305822046917,"self_endowment_contribution":0.5676284450877392,"citer_contribution":1.0486305822046917,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":33,"citers_with_citation_signal":28,"citers_with_endowment":28,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1716679,"name":"Katsuhiko Yoshizawa","orcid":null,"position":1,"is_corresponding":false},{"id":1716680,"name":"Nobuaki Shikata","orcid":null,"position":2,"is_corresponding":false},{"id":1696010,"name":"Miyo Matsumura","orcid":null,"position":3,"is_corresponding":false},{"id":1716681,"name":"Airo Tsubura","orcid":null,"position":4,"is_corresponding":false},{"id":1716678,"name":"Katsuji Kiuchi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nicotinamide Prevents N -methyl- N -nitrosourea-induced Photoreceptor Cell Apoptosis in Sprague-Dawley Rats and C57BL Mice","abstract":"In previous studies, it was found that a single systemic administration of N-methyl-N-nitrosourea (MNU) to rats and mice resulted in the retinal degeneration in all treated animals over a 7 day period. Retinal degeneration was due to photoreceptor cell apoptosis that was identical to the apoptosis seen in human retinitis pigmentosa (RP). In the present study, nicotinamide (NAM), a water-soluble B-group vitamin (vitamin B(3)), suppressed photoreceptor cell loss in a dose-dependent manner when administered immediately after MNU treatment. In rats, a dose of NAM >or=25 mg kg(-1) completely suppressed photoreceptor cell loss, and 10 mg kg(-1) partially suppressed photoreceptor cell loss. In mice, doses of 1000 and >or=100 mg kg(-1) were needed for complete and partial suppression, respectively. Thus, rats were more responsive to NAM than mice. The retinoprotective effect of 1000 mg kg(-1) NAM lasted throughout the long-term (35 days) observation period, with no apparent toxicity. Also, in rats, 1000 mg kg(-1) NAM completely suppressed photoreceptor cell loss when administered up to 4 hr after MNU treatment, and partially suppressed photoreceptor cell loss when administered 6 hr after MNU treatment. In mice, administration of NAM 2-6 hr after MNU resulted in partial suppression. NAM did not reduce levels of 7-methyldeoxyguanosine DNA adduct, but did reduce photoreceptor cell apoptosis. Although the mechanism of action underlying this retinoprotection remains to be clarified, NAM may be a potential therapeutic agent for the treatment of retinal degeneration.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12014919","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"12671728","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"13671857","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014483501911273?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014483501911273?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Retina","Animals","Mice, Inbred C57BL","Mice","Rats","Rats, Sprague-Dawley","Retinitis Pigmentosa","Disease Models, Animal","Methylnitrosourea","Niacinamide","Alkylating Agents","In Situ Nick-End Labeling","Apoptosis","Dose-Response Relationship, Drug","Female","Photoreceptor Cells, Vertebrate"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T01:45:44.782540Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}