{"doi":"10.1006/dbio.1999.9475","title":"Bilaterian Origins: Significance of New Experimental Observations","abstract":null,"journal":"Developmental Biology","year":2000,"id":657975,"datarank":6.633921962733647,"base_score":4.919980925828125,"endowment":4.919980925828125,"self_citation_contribution":0.7379971388742189,"citation_network_contribution":5.895924823859429,"self_endowment_contribution":0.7379971388742189,"citer_contribution":5.895924823859429,"corpus_percentile":null,"corpus_rank":null,"citation_count":136,"citer_count":129,"citers_with_citation_signal":111,"citers_with_endowment":111,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1717615,"name":"R.Andrew Cameron","orcid":null,"position":1,"is_corresponding":false},{"id":75518,"name":"Eric H. Davidson","orcid":null,"position":2,"is_corresponding":false},{"id":228806,"name":"Kevin J. Peterson","orcid":"0000-0002-6780-0964","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Bilaterian Origins: Significance of New Experimental Observations","abstract":"Several recent laboratory observations that bear on the origin of the Bilateria are reviewed and interpreted in light of our set-aside cell theory for bilaterian origins. We first discuss new data concerning the phylogeny of bilaterian phyla. Next, we use systematic, molecular, and paleontological lines of evidence to argue that the latest common ancestor of echinoderms plus hemichordates used a maximal indirect mode of development. Furthermore, the latest common ancestor of molluscs and annelids was also indirectly developing. Finally, we discuss new data on Hox gene expression patterns which suggest that both sea urchins and polychaete annelids use Hox genes in a very similar fashion. Neither utilizes the complete Hox complex in the development of the larva per se, while the Hox complex is expressed in the set-aside cells from which the adult body plan is formed. Our current views on the ancestry of the bilaterians are summarized in phylogenetic terms, incorporating the characters discussed in this paper.","is_dataset_classified":null,"base_score":4.919980925828125,"endowment":4.919980925828125,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10677251","pmcid":null,"openalex_id":"https://openalex.org/W2022880235","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"HD-05753","title":null}],"total_grants":1,"fwci":49.0003,"citation_percentile":0.99959333,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2025,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0012160699994757/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0012160699994757/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1006/dbio.1999.9475","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10677251","host_type":"repository"},{"url":"https://authors.library.caltech.edu/35090/","host_type":"repository"},{"url":"https://authors.library.caltech.edu/63874/","host_type":"repository"}],"fields_of_study":["Echinoderm biology and ecology","Marine Biology and Ecology Research","Marine and coastal plant biology","Animals","Annelida","Biological Evolution","Chordata, Nonvertebrate","Echinodermata","Gene Expression Regulation, Developmental","Genes, Homeobox","Invertebrates","Models, Biological","Mollusca","Multigene Family","Phylogeny"],"mesh_terms":["Animals","Annelida","Chordata, Nonvertebrate","Echinodermata","Biological Evolution","Genes, Homeobox","Multigene Family","Invertebrates","Models, Biological","Mollusca","Phylogeny","Gene Expression Regulation, Developmental"],"keywords":["Bilateria","Biology","Hox gene","Body plan","Phylum","Ancestor","Evolutionary biology","Phylogenetics","Most recent common ancestor","Phylogenetic tree","Echinoderm","Gene","Paleontology","Genetics","Gene expression","Non-programmatic"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:55:11.727399Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}