{"doi":"10.1006/cyto.2000.0796","title":"DISSOCIATION OF LPS-INDUCED MONOCYTIC EX VIVO PRODUCTION OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND TNF-α IN PATIENTS WITH SEPTIC SHOCK","abstract":null,"journal":"Cytokine","year":2001,"id":632659,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1640015,"name":"Guenther Fischer","orcid":null,"position":1,"is_corresponding":false},{"id":1258799,"name":"Eberhard Barth","orcid":null,"position":2,"is_corresponding":false},{"id":1640016,"name":"Eva Boneberg","orcid":null,"position":3,"is_corresponding":false},{"id":1640017,"name":"Elisabeth-Marion Schneider","orcid":null,"position":4,"is_corresponding":false},{"id":225655,"name":"Michael Georgieff","orcid":"0000-0003-0844-6907","position":5,"is_corresponding":false},{"id":88072,"name":"Thomas Hartung","orcid":null,"position":6,"is_corresponding":false},{"id":1640014,"name":"Manfred Weiss","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DISSOCIATION OF LPS-INDUCED MONOCYTIC EX VIVO PRODUCTION OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND TNF-α IN PATIENTS WITH SEPTIC SHOCK","abstract":"Over a 6 month period, in 192 patients admitted to the intensive care unit (ICU), a longitudinal analysis of whole blood lipopolysaccharide (LPS)-induced ex vivo cytokine production was performed on a daily basis until discharge from the ICU or death. Twenty-one patients with proven infections were in septic shock for the first time and for at least 3 days' duration. Ex vivo LPS-inducible release of granulocyte colony-stimulating factor (G-CSF) was upregulated and that of TNF-alpha was downregulated in patients with septic shock, regardless whether they survived or died. In conclusion, LPS-induced ex vivo TNF-alpha and G-CSF cytokine release by monocytes is regulated differentially in patients with septic shock. Since upregulation of LPS-induced production of G-CSF occurred earlier in survivors than in non-survivors, rapidly elevated and sustained G-CSF responsiveness may contribute to survival in septic shock.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11145842","pmcid":null,"openalex_id":"https://openalex.org/W2006380937","authors":[],"funders":[],"total_grants":0,"fwci":0.8664,"citation_percentile":0.71481977,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1043466600907968?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1043466600907968?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/cyto.2000.0796","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11145842","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Sepsis Diagnosis and Treatment","Adrenal Hormones and Disorders","Adult","Aged","Aged, 80 and over","Critical Care","Down-Regulation","Female","Granulocyte Colony-Stimulating Factor","Humans","In Vitro Techniques","Lipopolysaccharides","Male","Middle Aged","Monocytes","Prognosis","Shock, Septic","Tumor Necrosis Factor-alpha","Up-Regulation"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Critical Care","Female","Humans","Lipopolysaccharides","Male","Middle Aged","Monocytes","Prognosis","Shock, Septic","Tumor Necrosis Factor-alpha","Down-Regulation","Up-Regulation","Granulocyte Colony-Stimulating Factor","In Vitro Techniques"],"keywords":["Ex vivo","Septic shock","Lipopolysaccharide","Medicine","Tumor necrosis factor alpha","Cytokine","Granulocyte colony-stimulating factor","In vivo","Granulocyte","Sepsis","Immunology","Intensive care","Shock (circulatory)","Intensive care unit","Internal medicine","Biology","Intensive care medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:08:03.862843Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}