{"doi":"10.1006/cimm.1999.1555","title":"Dendritic Cell Maturation and Subsequent Enhanced T-Cell Stimulation Induced with the Novel Synthetic Immune Response Modifier R-848","abstract":null,"journal":"Cellular Immunology","year":1999,"id":601246,"datarank":0.7218276533058626,"base_score":4.812184355372417,"endowment":4.812184355372417,"self_citation_contribution":0.7218276533058626,"citation_network_contribution":0.0,"self_endowment_contribution":0.7218276533058626,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":122,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1541582,"name":"Sheila J. Gibson","orcid":null,"position":1,"is_corresponding":false},{"id":1541583,"name":"Rose M. Smith","orcid":null,"position":2,"is_corresponding":false},{"id":1541584,"name":"Linda K. Pederson","orcid":null,"position":3,"is_corresponding":false},{"id":1541585,"name":"Jana M. Lindh","orcid":null,"position":4,"is_corresponding":false},{"id":225988,"name":"Mark A. Tomai","orcid":"0000-0002-6362-9151","position":5,"is_corresponding":false},{"id":253819,"name":"John P. Vasilakos","orcid":"0000-0002-1075-9665","position":6,"is_corresponding":false},{"id":1182967,"name":"Cory L. Ahonen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dendritic Cell Maturation and Subsequent Enhanced T-Cell Stimulation Induced with the Novel Synthetic Immune Response Modifier R-848","abstract":"Agents that enhance dendritic cell maturation can enhance T-cell activation and therefore may improve the efficiency of vaccines or improve cellular immunotherapy. Previously, we demonstrated that a novel low-molecular-weight synthetic immune response modifier, R-848, induces IL-12 and IFN-alpha secretion from monocytes and macrophages. Here we report that R-848 induces the maturation of human monocyte-derived dendritic cells. Characteristic of dendritic cell maturation, R-848 treatment induces cell surface expression of CD83 and increases cell surface expression of CD80, CD86, CD40, and HLA-DR. Additionally, R-848 induces cytokine (IL-6, IL-12, TNF-alpha, IFN-alpha) and chemokine (IL-8, MIP-1alpha, MCP-1) secretion from dendritic cells. Most significantly, R-848 enhances dendritic cell antigen presenting function, as measured by increased T-cell proliferation and T-cell cytokine secretion in both allogeneic and autologous T-cell systems. Consequently, low-molecular-weight synthetic molecules such as R-848 and its derivatives may be useful as vaccine adjuvants or as ex vivo stimulators of dendritic cells for cellular immunotherapy.","is_dataset_classified":null,"base_score":4.812184355372417,"endowment":4.812184355372417,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10555997","pmcid":null,"openalex_id":"https://openalex.org/W2058042075","authors":[],"funders":[],"total_grants":0,"fwci":1.7898,"citation_percentile":0.85399308,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":7},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":5},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0008874999915551?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0008874999915551?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/cimm.1999.1555","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10555997","host_type":"repository"}],"fields_of_study":["Immunotherapy and Immune Responses","Immune Cell Function and Interaction","T-cell and B-cell Immunology","Antigens, CD","Antigens, Surface","Cell Differentiation","Cell Division","Cells, Cultured","Chemokines","Cytokines","Dendritic Cells","Dose-Response Relationship, Drug","Flow Cytometry","Humans","Imidazoles","Lipopolysaccharides","Lymphocyte Activation","Monocytes","T-Lymphocytes","Tumor Necrosis Factor-alpha"],"mesh_terms":["Antigens, Surface","Cell Differentiation","Cell Division","Cells, Cultured","Dendritic Cells","Dose-Response Relationship, Drug","Flow Cytometry","Humans","Imidazoles","Lipopolysaccharides","Lymphocyte Activation","Monocytes","T-Lymphocytes","Tumor Necrosis Factor-alpha","Antigens, CD","Cytokines","Chemokines"],"keywords":["CD80","CD86","Dendritic cell","Antigen-presenting cell","T cell","Cell biology","CD40","Chemokine","Biology","Immune system","Cytokine","Immunotherapy","Secretion","Immunology","Chemistry","Cytotoxic T cell","In vitro","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T15:37:56.191282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}