{"doi":"10.1006/bbrc.1996.0467","title":"Comparative Analysis of the Regions Binding βγ-Subunits in Gα and PH Domains","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":1996,"id":617114,"datarank":0.5963851697924005,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.2844689385404251,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.2844689385404251,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":606050,"name":"Michael D. Waterfield","orcid":null,"position":1,"is_corresponding":false},{"id":329601,"name":"Tom L. Blundell","orcid":"0000-0002-2708-8992","position":2,"is_corresponding":false},{"id":72753,"name":"N. Srinivasan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparative Analysis of the Regions Binding βγ-Subunits in Gα and PH Domains","abstract":"Some of the pleckstrin homology (PH) domains are shown to bind beta gamma-subunits of a G-protein. In this paper we present a detailed comparison of sequences and structural features of beta gamma-binding regions in PH domains and alpha-subunits (G alpha) of known structure. Our comparison involves switch II region in G alpha and a C-terminal region of PH domain structures and we suggest a similarity in these regions. By comparing the active and inactive forms of G alpha structures we predict that some of the bulky hydrophobic residues in switch II region might interact with beta gamma-subunits. Subsequent to completion of this work we find that this prediction is absolutely consistent with recently reported crystal structures of heterotrimeric G-proteins. We discuss the feasibility of common principles in the recognition G alpha and PH domains by beta gamma-subunits.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8607828","pmcid":null,"openalex_id":"https://openalex.org/W2158446945","authors":[],"funders":[],"total_grants":0,"fwci":1.6929,"citation_percentile":0.84301385,"influential_citations":0,"citation_trend":[{"year":2022,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X96904672?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X96904672?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/bbrc.1996.0467","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8607828","host_type":"repository"}],"fields_of_study":["Enzyme Structure and Function","Ubiquitin and proteasome pathways","Protein Structure and Dynamics","Amino Acid Sequence","Animals","Binding Sites","Blood Proteins","Computer Graphics","Databases, Factual","Dynamins","GTP Phosphohydrolases","GTP-Binding Proteins","Guanosine Triphosphate","Humans","Macromolecular Substances","Models, Structural","Molecular Sequence Data","Phosphoproteins","Protein Structure, Secondary","Sequence Homology, Amino Acid","Software","Transducin","src Homology Domains"],"mesh_terms":["Amino Acid Sequence","Animals","Binding Sites","Blood Proteins","Computer Graphics","Guanosine Triphosphate","Humans","Models, Structural","Molecular Sequence Data","Phosphoproteins","Software","Transducin","Databases, Factual","Sequence Homology, Amino Acid","Protein Structure, Secondary","src Homology Domains","GTP-Binding Proteins","GTP Phosphohydrolases","Dynamins","Macromolecular Substances"],"keywords":["Heterotrimeric G protein","Pleckstrin homology domain","Protein subunit","Sequence homology","Homology (biology)","Chemistry","Binding site","Homology modeling","Crystallography","Domain (mathematical analysis)","Sequence (biology)","Similarity (geometry)","Biochemistry","Peptide sequence","Amino acid","G protein","Receptor","Computer science","Enzyme","Signal transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T00:51:53.520829Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}