{"doi":"10.1006/bbrc.1994.2580","title":"Purification and Characterization of Brain Clusterin","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":1994,"id":678805,"datarank":0.7143260902196635,"base_score":4.762173934797756,"endowment":4.762173934797756,"self_citation_contribution":0.7143260902196635,"citation_network_contribution":0.0,"self_endowment_contribution":0.7143260902196635,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":116,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1773567,"name":"G.M. Pasinetti","orcid":null,"position":1,"is_corresponding":false},{"id":1773568,"name":"H.H. Osterburg","orcid":null,"position":2,"is_corresponding":false},{"id":903164,"name":"C. Anderson","orcid":"0000-0003-4211-5765","position":3,"is_corresponding":false},{"id":779526,"name":"S.A. Johnson","orcid":"0000-0002-0244-5201","position":4,"is_corresponding":false},{"id":1773572,"name":"C.E. Finch","orcid":null,"position":5,"is_corresponding":false},{"id":1773565,"name":"T. Oda","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Purification and Characterization of Brain Clusterin","abstract":"Clusterin, a 70-80 kDa sulfated glycoprotein found in numerous tissues, is also known as complement lysis inhibitor (CLI), apolipoprotein J, SP-40,40, TRPM-2, and SGP-2. In Alzheimer disease (AD), clusterin mRNA is increased, whereas clusterin protein is found in deposits of beta-amyloid (A beta). These studies characterized clusterin protein from human brain. In extracts from cortex and hippocampus, clusterin was about 40% higher in AD than in controls. Purified clusterin from human brain was slightly smaller than serum clusterin. Brain and serum clusterin were indistinguishable in the inhibition of complement-mediated hemolysis. Both serum and brain clusterin were indistinguishable in inhibiting the aggregation of A beta and promoting oxidative stress in rat pheochromocytoma PC12 cells (MTT assay). The inhibition of A beta aggregation and enhancement of A beta toxicity by clusterin suggest new mechanisms in AD.","is_dataset_classified":null,"base_score":4.762173934797756,"endowment":4.762173934797756,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7980587","pmcid":null,"openalex_id":"https://openalex.org/W1999486225","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"AG-7909","title":null}],"total_grants":1,"fwci":1.3046,"citation_percentile":0.8280864,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":8},{"year":2014,"count":4},{"year":2015,"count":10},{"year":2016,"count":3},{"year":2017,"count":5},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X84725800?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X84725800?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/bbrc.1994.2580","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7980587","host_type":"repository"}],"fields_of_study":["Clusterin in disease pathology","Bioinformatics and Genomic Networks","Machine Learning in Bioinformatics"],"mesh_terms":["Alzheimer Disease","Animals","Antibodies, Monoclonal","Brain","Cerebral Cortex","Complement Inactivator Proteins","Dose-Response Relationship, Drug","Electrophoresis, Polyacrylamide Gel","Erythrocytes","Glycoproteins","Guinea Pigs","Hemolysis","Hippocampus","Humans","Hybridomas","Molecular Weight","Reference Values","RNA, Messenger","Immunoblotting","Gene Expression","Molecular Chaperones","Clusterin"],"keywords":["Clusterin","Chemistry","Molecular biology","Human brain","Amyloid (mycology)","Biology","Biochemistry","Apoptosis","Neuroscience"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T11:29:53.839747Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}