{"doi":"10.1006/bbrc.1994.1520","title":"NGF-Induced Stabilization of Gap-43 mRNA Is Mediated by Both 3′ Untranslated Region and a Segment Encoding the Carboxy-Terminus Peptide","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":1994,"id":619180,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1597757,"name":"K. Nishizawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"NGF-Induced Stabilization of Gap-43 mRNA Is Mediated by Both 3′ Untranslated Region and a Segment Encoding the Carboxy-Terminus Peptide","abstract":"NGF stabilizes cytoplasmic mRNA for GAP-43, a neuronal growth cone protein. A 292 b segment of rat GAP-43 mRNA was determined to mediate this stabilizing effect. Insertion of the 292 b segment into heterologous mRNA was also shown to constitutively destabilize the mRNA in the absence of NGF. This 292 b segment contains the sequences encoding the carboxy-terminus peptide and part of the 3' untranslated region. Neither one of these sequences can fully mediate the NGF-dependent stability control independently from each other. Premature termination of translation before the 292 b segment reduces both the constitutive destabilization by the 292 b segment and the NGF-induced stabilization. These findings indicate that the constitutive destabilizing function of the 292 b segment is dependent on the direct translation of this segment and that NGF suppresses the destabilizing function of this segment.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8179613","pmcid":null,"openalex_id":"https://openalex.org/W2016832127","authors":[],"funders":[],"total_grants":0,"fwci":1.0921,"citation_percentile":0.76023291,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X84715208?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X84715208?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1006/bbrc.1994.1520","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8179613","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA Interference and Gene Delivery","RNA and protein synthesis mechanisms","Animals","Dactinomycin","Drug Stability","GAP-43 Protein","Genetic Vectors","Half-Life","Membrane Glycoproteins","Nerve Growth Factors","Nerve Tissue Proteins","PC12 Cells","Protein Biosynthesis","RNA, Messenger","Rats","Transcription, Genetic"],"mesh_terms":["Animals","Dactinomycin","Drug Stability","Genetic Vectors","Half-Life","Membrane Glycoproteins","Nerve Growth Factors","Nerve Tissue Proteins","RNA, Messenger","Transcription, Genetic","Protein Biosynthesis","PC12 Cells","GAP-43 Protein","Rats"],"keywords":["Messenger RNA","Untranslated region","Translation (biology)","Three prime untranslated region","Biology","Peptide","Molecular biology","Cell biology","Genetics","Gene","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T06:16:38.820551Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}