{"doi":"10.1002/yea.1389","title":"<i>In vitro</i> synergistic effect of farnesol and human gingival cells against <i>Candida albicans</i>","abstract":"<jats:title>Abstract</jats:title><jats:p>Farnesol prevents the germination of yeast cells into mycelia, a fact that may be useful in eliminating <jats:italic>C. albicans</jats:italic> pathogenicity. Given the clinical potential of farnesol, its impact on <jats:italic>C. albicans</jats:italic> and host cells merited further investigation. We thus studied the effect of farnesol on <jats:italic>C. albicans</jats:italic> growth and filamentation and on gingival epithelial cells and fibroblasts and the synergistic effect of both gingival cells and farnesol on <jats:italic>C. albicans</jats:italic> filamentation. Repeated additions of farnesol reduced the growth of <jats:italic>C. albicans</jats:italic>. Farnesol was also effective at reducing <jats:italic>C. albicans</jats:italic> germ tube formation. While farnesol inhibited germ tube formation under the conditions tested, it was most effective at inhibiting <jats:italic>C. albicans</jats:italic> filamentation when added to the culture medium at the same time as the serum. Farnesol also had an effect on gingival cells. In a serum‐free medium, farnesol reduced fibroblast adhesion and proliferation, promoted epithelial cell differentiation and reduced proliferation up to 48 h post‐treatment. These effects were not seen in the presence of serum. When <jats:italic>C. albicans</jats:italic>, farnesol and gingival cells were present in the same culture, significantly greater inhibition of the yeast‐to‐hyphal transition was observed than germ tube inhibition in cultures containing only <jats:italic>C. albicans</jats:italic> and farnesol, suggesting a synergistic effect between the gingival cells and farnesol in inhibiting the transition. Overall, the data suggest that farnesol is effective against <jats:italic>C. albicans</jats:italic> and may have an effect on host cells at certain concentrations. Copyright © 2006 John Wiley &amp; Sons, Ltd.</jats:p>","journal":"Yeast","year":2006,"id":601664,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1542771,"name":"Cyril Luitaud","orcid":null,"position":1,"is_corresponding":false},{"id":1542772,"name":"Mahmoud Rouabhia","orcid":null,"position":2,"is_corresponding":false},{"id":1542770,"name":"Said Saidi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<i>In vitro</i> synergistic effect of farnesol and human gingival cells against <i>Candida albicans</i>","abstract":"<jats:title>Abstract</jats:title><jats:p>Farnesol prevents the germination of yeast cells into mycelia, a fact that may be useful in eliminating <jats:italic>C. albicans</jats:italic> pathogenicity. Given the clinical potential of farnesol, its impact on <jats:italic>C. albicans</jats:italic> and host cells merited further investigation. We thus studied the effect of farnesol on <jats:italic>C. albicans</jats:italic> growth and filamentation and on gingival epithelial cells and fibroblasts and the synergistic effect of both gingival cells and farnesol on <jats:italic>C. albicans</jats:italic> filamentation. Repeated additions of farnesol reduced the growth of <jats:italic>C. albicans</jats:italic>. Farnesol was also effective at reducing <jats:italic>C. albicans</jats:italic> germ tube formation. While farnesol inhibited germ tube formation under the conditions tested, it was most effective at inhibiting <jats:italic>C. albicans</jats:italic> filamentation when added to the culture medium at the same time as the serum. Farnesol also had an effect on gingival cells. In a serum‐free medium, farnesol reduced fibroblast adhesion and proliferation, promoted epithelial cell differentiation and reduced proliferation up to 48 h post‐treatment. These effects were not seen in the presence of serum. When <jats:italic>C. albicans</jats:italic>, farnesol and gingival cells were present in the same culture, significantly greater inhibition of the yeast‐to‐hyphal transition was observed than germ tube inhibition in cultures containing only <jats:italic>C. albicans</jats:italic> and farnesol, suggesting a synergistic effect between the gingival cells and farnesol in inhibiting the transition. Overall, the data suggest that farnesol is effective against <jats:italic>C. albicans</jats:italic> and may have an effect on host cells at certain concentrations. Copyright © 2006 John Wiley &amp; Sons, Ltd.</jats:p>","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16845684","pmcid":null,"openalex_id":"https://openalex.org/W2086675747","authors":[],"funders":[],"total_grants":0,"fwci":1.2057,"citation_percentile":0.77601199,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fyea.1389","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/yea.1389","host_type":"publisher"},{"url":"https://doi.org/10.1002/yea.1389","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16845684","host_type":"repository"}],"fields_of_study":["Antifungal resistance and susceptibility","Candida albicans","Candidiasis, Oral","Cell Adhesion","Cell Proliferation","Cells, Cultured","Epithelial Cells","Farnesol","Fibroblasts","Gingiva","Humans","Mouth Diseases"],"mesh_terms":["Candida albicans","Candidiasis, Oral","Cell Adhesion","Cells, Cultured","Epithelial Cells","Farnesol","Fibroblasts","Gingiva","Humans","Mouth Diseases","Cell Proliferation"],"keywords":["Farnesol","Candida albicans","Germ tube","Corpus albicans","Biology","Microbiology","Filamentation","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T17:02:51.753774Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}